SCNN1G Rabbit Polyclonal Antibody (ER1803-61)

UNIPROT #

P51170

PROTEIN NAME

SCNN1G

SYNONYMS

Amiloride sensitive epithelial sodium channel gamma subunit antibody;Amiloride sensitive sodium channel subunit gamma antibody;Amiloride-sensitive sodium channel subunit gamma antibody;BESC3 antibody;ENaC gamma subunit antibody;ENaCG antibody;ENaCgamma antibody;Epithelial Na(+) channel subunit gamma antibody;Epithelial Na+ channel subunit gamma antibody;Gamma ENaC antibody;Gamma NaCH antibody;Gamma-ENaC antibody;Gamma-NaCH antibody;Nonvoltage gated sodium channel 1 subunit gamma antibody;Nonvoltage-gated sodium channel 1 subunit gamma antibody;PHA 1 antibody;PHA1 antibody;SCNEG antibody;SCNN 1G antibody;SCNN1G antibody;SCNNG_HUMAN antibody;Sodium channel epithelial 1 gamma subunit antibody;Sodium channel non voltage gated 1 gamma subunit antibody;Sodium channel nonvoltage gated 1 gamma antibody

SEQUENCE SIMILARITIES

Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. SCNN1G subfamily.

TISSUE SPECIFICITY

Expressed in kidney (at protein level).

POST-TRANSLATIONAL MODIFICATION

Phosphorylated on serine and threonine residues. Aldosterone and insulin increase the basal level of phosphorylation.; Ubiquitinated; this targets individual subunits for endocytosis and proteasome-mediated degradation.; ENaC cleavage by furin, and subsequently by prostasin (PRSS8), leads to a stepwise increase in the open probability of the channel as a result of release of the alpha and gamma subunit inhibitory tracts, respectively. Interaction of ENaC subunit SCNN1B with BPIFA1 protects ENaC against proteolytic activation.

SUBCELLULAR LOCATION

Apical cell membrane, plasma membrane, nucleoplasm.

FUNCTION

Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception.