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VAMP8 Recombinant Rabbit Monoclonal Antibody [JF0963] (ET1702-10)

Price: Regular price $385.00

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Catalog# ET1702-10

Rabbit Monoclonal to VAMP8

Tested for

  • WB

  • IF-Cell

  • IF-Tissue

  • IHC-P

  • IP

  • FC

Reacts with

  • Human

  • Mouse

  • Rat

Recombinant production enables lot-to-lot consistency and is animal-cruelty-free
This product has been cited in peer reviewed publications, see list HERE

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Specifications

Product Type

Recombinant Rabbit monoclonal primary

Product Name

VAMP8 Recombinant Rabbit Monoclonal Antibody [JF0963] (ET1702-10)

Immunogen

Synthetic peptide wiithin human vamp8 aa1-29 / 100.

Host

Rabbit

Positive Control

Hela cell lysate, mouse kidney tissue lysate, U937 cell lysates, SW480, 293T, Hela, human kidney tissue, mouse kidney tissue, rat kidney tissue.

Conjugation

Unconjugated

Clonality

Monoclonal

Clone Number

JF0963

RRID

AB_3070273

APPLICATION DILUTION

  • WB

  • 1:1,000-1:2,000

  • IF-Cell

  • 1:50-1:100

  • IF-Tissue

  • 1:1,000

  • IHC-P

  • 1:5,000

  • FC

  • 1:50-1:100

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1ug/ul

Purification

Protein A affinity purified.

Molecular Weight

Predicted band size: 11 kDa

Isotype

IgG

TARGET

UNIPROT #

Q9BV40

PROTEIN NAME

VAMP8

SYNONYMS

EDB antibody;Endobrevin antibody;VAMP 8 antibody;VAMP-8 antibody;VAMP8 antibody;VAMP8_HUMAN antibody;Vesicle associated membrane protein 8 antibody;Vesicle-associated membrane protein 8 antibody

SEQUENCE SIMILARITIES

Belongs to the synaptobrevin family.

TISSUE SPECIFICITY

Platelets.

SUBCELLULAR LOCATION

Lysosome membrane, Early endosome membrane, Late endosome membrane, Cell membrane.

FUNCTION

Vesicle-associated membrane protein 8 is a protein that in humans is encoded by the VAMP8 gene.Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. It is associated with the perinuclear vesicular structures of the early endocytic compartment. It has been found that VAMP8 interacts specifically with the soluble NSF-attachment protein (alpha-SNAP), most likely through an VAMP8-containing SNARE complex.Phosphorylation of VAMP8 inside the conserved SNARE-domain can suppress vesicle fusion.

CITATIONS

  • Inhibition of STX17–SNAP29–VAMP8 complex formation by costunolide sensitizes ovarian cancer cells to cisplatin via the AMPK/mTOR signaling pathway

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