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Butyrylcholine esterase Rabbit Polyclonal Antibody (HA500248)

Price: Regular price $315.00

Volume

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Catalog# HA500248

Rabbit Polyclonal to Butyrylcholine esterase

Tested for

  • WB

  • IF-Cell

  • IHC-P

Reacts with

  • Human

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Specifications

Product Type

Rabbit polyclonal primary

Product Name

Butyrylcholine esterase Rabbit Polyclonal Antibody (HA500248)

Immunogen

Recombinant protein within human butyrylcholine esterase aa 300-510.

Host

Rabbit

Positive Control

Human skin tissue lysates, HepG2, LOVO, MCF-7, human liver tissue, human prostate tissue.

Conjugation

Unconjugated

Clonality

Polyclonal

RRID

AB_3071344

APPLICATION DILUTION

  • WB:1:1,000

  • IF-Cell

  • 1:100

  • IHC-P

  • 1:100

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*TBS (pH7.4), 1%BSA, 50%Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1ug/ul

Purification

Immunogen affinity purified.

Molecular Weight

Predicted band size: 68 kDa

Isotype

IgG

TARGET

UNIPROT #

P06276

PROTEIN NAME

Butyrylcholine esterase

SYNONYMS

Acylcholine acylhydrolase antibody;BCHE antibody;Butyrylcholine esterase antibody;CHE1 antibody;CHE2 antibody;CHLE_HUMAN antibody;Choline esterase II antibody;Cholinesterase (serum) 2 antibody;Cholinesterase 1 antibody;Cholinesterase antibody;E1 antibody;Pseudocholinesterase antibody;Pseudocholinesterase E1 antibody

SUBCELLULAR LOCATION

Secreted.

FUNCTION

Present in most cells except erythrocytes, butyrylcholine esterase (BChE), also designated acylcholine acylhydrolase or pseudocholinesterase, has esterase activity as well as aryl acylamidase activity. It hydrolyzes acylcholine into choline and carboxylate. BChE is synthesized in the liver and is highly reactive with organophosphate esters. BChE can form a homotetramer composed of two dimers linked by a disulfide bond. Defects in the gene encoding BChE are associated with the disease hypocholinesterasemia. Inhibition of BChE effects the toxicity of organophosphates in the respiratory system suggesting that BChE may play a role in respiratory function. In addition, BChE may play an important pharmocological role by hydrolyzing toxic esters. This suggests an involvement of BChE in a treatment for intoxication with substances such as cocaine.

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