GABRA4 Rabbit Polyclonal Antibody (ER1901-60)

UNIPROT #

P48169

PROTEIN NAME

GABRA4

SYNONYMS

GABA(A) receptor subunit alpha 4 antibody;GABA(A) receptor subunit alpha-4 antibody;GABR A4 antibody;GABRA 4 antibody;Gabra4 antibody;Gamma aminobutyric acid (GABA) A receptor alpha 4 antibody;Gamma aminobutyric acid A receptor alpha 4 antibody;Gamma aminobutyric acid receptor alpha 4 subunit antibody;Gamma aminobutyric acid receptor subunit alpha 4 antibody;Gamma-aminobutyric acid receptor subunit alpha-4 antibody;GBRA4_HUMAN antibody

SEQUENCE SIMILARITIES

Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA4 sub-subfamily.

SUBCELLULAR LOCATION

Postsynaptic cell membrane, cell membrane.

FUNCTION

Gamma-aminobutyric acid receptor subunit alpha-4 is a protein that in humans is encoded by the GABRA4 gene. Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. This gene encodes subunit alpha-4, which is involved in the etiology of autism and eventually increases autism risk through interaction with another subunit, gamma-aminobutyric acid receptor beta-1 (GABRB1). Alternatively spliced transcript variants encoding different isoforms have been found in this gene.