GluA4 Recombinant Rabbit Monoclonal Antibody [JE36-81] (HA721582)

UNIPROT #

P48058

PROTEIN NAME

GluA4

SYNONYMS

AMPA 4 antibody;AMPA selective glutamate receptor 4 antibody;AMPA-selective glutamate receptor 4 antibody;AMPA4 antibody;GluA 4 antibody;GluA4 antibody;GluR 4 antibody;GluR D antibody;GluR-4 antibody;GluR-D antibody;GluR4 antibody;GLUR4C antibody;GLURD antibody;Glutamate receptor 4 antibody;Glutamate receptor ionotrophic AMPA 4 antibody;Glutamate receptor ionotropic antibody;GRIA 4 antibody;Gria4 antibody;GRIA4_HUMAN antibody;Ionotropic Glutamate receptor 4 antibody

SUBCELLULAR LOCATION

Cell membrane. Cell junction > synapse > postsynaptic cell membrane.

FUNCTION

Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds AMPA (quisqualate) > glutamate > kainate.