GluR2 Recombinant Rabbit Monoclonal Antibody [JU20-43] (ET1706-06)

UNIPROT #

P42262

PROTEIN NAME

GluR2

SYNONYMS

AMPA 2 antibody;AMPA selective glutamate receptor 2 antibody;AMPA-selective glutamate receptor 2 antibody;AMPA2 antibody;GluA2 antibody;GLUR 2 antibody;GLUR B antibody;GluR K2 antibody;GluR-2 antibody;GluR-B antibody;GluR-K2 antibody;GLUR2 antibody;GLURB antibody;Glutamate receptor 2 antibody;Glutamate receptor ionotropic AMPA 2 antibody;Glutamate receptor ionotropic antibody;Gria2 antibody;GRIA2_HUMAN antibody;HBGR2 antibody

SEQUENCE SIMILARITIES

Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIA2 subfamily.

POST-TRANSLATIONAL MODIFICATION

Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-610 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast, Cys-836 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis (By similarity).; Phosphorylation at Tyr-876 is required forc interaction with IQSEC1 and ARF6 activation.

SUBCELLULAR LOCATION

Cell membrane, postsynaptic cell membrane, postsynaptic density membrane, endoplasmic reticulum membrane.

FUNCTION

Lonotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.