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mGluR6 Rabbit Polyclonal Antibody (HA500158)

Price: Regular price $315.00

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Catalog# HA500158

Rabbit Polyclonal to mGluR6

Tested for

  • WB

  • IF-Cell

  • IHC-P

  • FC

Reacts with

  • Human

Safety datasheet

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Specifications

Product Type

Rabbit polyclonal primary

Product Name

mGluR6 Rabbit Polyclonal Antibody (HA500158)

Immunogen

Synthetic peptide within human mglur6 aa 820-877.

Host

Rabbit

Positive Control

HepG2 cell lysates, SHSY5Y.

Conjugation

Unconjugated

Clonality

Polyclonal

RRID

AB_3071255

APPLICATION DILUTION

  • WB

  • 1:500-1:1,000

  • IF-Cell

  • 1:50-1:200

  • IHC-P

  • 1:50-1:200

  • FC

  • 1:50-1:100

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1ug/ul

Purification

Immunogen affinity purified.

Molecular Weight

Predicted band size: 95 kDa.

Isotype

IgG

TARGET

UNIPROT #

O15303

PROTEIN NAME

mGluR6

SYNONYMS

CSNB1B antibody;DKFZp686H1993 antibody;GluR6 antibody;Glutamate receptor metabotropic 6 antibody;GPRC1F antibody;Grm6 antibody;GRM6_HUMAN antibody;Metabotropic glutamate receptor 6 antibody;mGlu6 antibody;mGluR6 antibody

SUBCELLULAR LOCATION

Cell membrane, Cell projection, Endoplasmic reticulum, Golgi apparatus, Membrane.

FUNCTION

mGluR6 is specifically expressed in the retina, in a subtype of bipolar cells that depolarize in response to light, known as ON bipolar cells. These cells form synapses with photoreceptor cells, and detect the neurotransmitter glutamate via a GPCR signal transduction cascade. The glutamate receptor mGluR6 is located post-synaptically at the tips of the bipolar cell dendrites, and is responsible for initiating a signaling cascade that ultimately controls gating of the TRPM1 channel. In human patients, mutations in the GRM6 gene are associated with congenital stationary night blindness.

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