Nucleoside Phosphorylase Rabbit Polyclonal Antibody (HA500062)

UNIPROT #

P00491

PROTEIN NAME

Nucleoside Phosphorylase

SYNONYMS

FLJ94043 antibody;FLJ97288 antibody;FLJ97312 antibody;Inosine phosphorylase antibody;Inosine-guanosine phosphorylase antibody;MGC117396 antibody;MGC125915 antibody;MGC125916 antibody;NP antibody;Np1 antibody;Nucleoside phosphorylase antibody;PNP antibody;Pnp1 antibody;PNPH_HUMAN antibody;PRO1837 antibody;PUNP antibody;Purine nucleoside orthophosphate ribosyltransferase antibody;Purine nucleoside phosphorylase 5a antibody;Purine nucleoside phosphorylase antibody

SUBCELLULAR LOCATION

Cytoplasm, Cytoskeleton.

FUNCTION

Purine nucleoside phosphorylase is an enzyme involved in purine metabolism. PNP metabolizes inosine into hypoxanthine and guanosine into guanine, in each case creating ribose phosphate. Note: adenosine is first metabolized to inosine via the enzyme adenosine deaminase.One of the reaction catalyzed by purine nucleoside phosphorylase in purine metabolism.Nucleoside phosphorylase is an enzyme which cleaves a nucleoside by phosphorylating the ribose to produce a nucleobase and ribose 1 phosphate. It is one enzyme of the nucleotide salvage pathways. These pathways allow the cell to produce nucleotide monophosphates when the de novo synthesis pathway has been interrupted or is non-existent (as is the case in the brain). Often the de novo pathway is interrupted as a result of chemotherapy drugs such as methotrexate or aminopterin.All salvage pathway enzymes require a high energy phosphate donor such as ATP or PRPP.