GABRB2 Rabbit Polyclonal Antibody (HA500289)

UNIPROT #

P47870

PROTEIN NAME

GABRB2

SYNONYMS

GABA antibody;GABA(A) receptor beta 2 antibody;GABA(A) receptor subunit beta-2 antibody;GABA-A receptor, beta-2 polypeptide antibody;GABRB2 antibody;Gamma aminobutyric acid (GABA) A receptor, beta 2 antibody;Gamma aminobutyric acid A receptor beta 2 antibody;Gamma-aminobutyric acid receptor subunit beta-2 antibody;Gamma-aminobutyric-acid receptor subunit beta-2 antibody;GBRB2_HUMAN antibody

SUBCELLULAR LOCATION

Cytoplasmic.

FUNCTION

Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel . The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer (By similarity). The alpha1/beta2/gamma2 receptor and the alpha2/beta2/gamma2 receptor exhibit synaptogenic activity . Functions also as histamine receptor and mediates cellular responses to histamine (By similarity).