PBP Recombinant Rabbit Monoclonal Antibody [SC58-09] (ET1610-18)

UNIPROT #

P30086

PROTEIN NAME

PBP

SYNONYMS

Epididymis luminal protein 210 antibody;Epididymis secretory protein Li 34 antibody;Epididymis secretory protein Li 96 antibody;HCNP antibody;HCNPpp antibody;HEL 210 antibody;HEL S 34 antibody;HEL S 96 antibody;Hippocampal cholinergic neurostimulating peptide antibody;Neuropolypeptide h3 antibody;PBP antibody;PEBP antibody;PEBP 1 antibody;PEBP-1 antibody;Pebp1 antibody;PEBP1_HUMAN antibody;Phosphatidylethanolamine binding protein antibody;Phosphatidylethanolamine binding protein 1 antibody;Prostatic binding protein antibody;Prostatic-binding protein antibody;R kip antibody;Raf kinase inhibitor protein antibody;Raf kinase inhibitory protein antibody;RKIP antibody

SEQUENCE SIMILARITIES

Belongs to the phosphatidylethanolamine-binding protein family.

SUBCELLULAR LOCATION

Cytoplasm.

FUNCTION

Members of the a-chemokine subfamily of inducible, secreted, pro-inflammatory cytokines contain a similar motif, in which the first two cysteine residues are separated by a single residue (Cys-X-Cys), and are also chemotactic for neutrophils. The platelet basic protein (PBP), a member of the a(lpha)-chemokine family, resides in the a(lpha)-granules of platelets and is released upon their activation. Proteolytic cleavage of the amino terminus of PBP leads to the generation of several peptides, which include mature PBP, connective tissue-activating peptide III (CTAP III, also designated low affinity platelet factor IV (LA-PF4)), b-thromboglobulin (b-TG), and neutrophil-activating peptide 2 (NAP-2). PBP and its N-truncated derivatives mediate inflammation and wound healing. Specifically, NAP-2 activates chemotaxis and degranulation in neutrophils during inflammation. The gene encoding human PBP maps to chromosome 4q12-q13.