POMC Recombinant Rabbit Monoclonal Antibody [JE32-88] (HA721250)

UNIPROT #

P01189

PROTEIN NAME

POMC

SYNONYMS

ACTH antibody;Adrenocorticotropic hormone antibody;Adrenocorticotropin antibody;alpha melanocyte stimulating hormone antibody;Alpha MSH antibody;Alpha-MSH antibody;beta endorphin antibody;Beta LPH antibody;beta melanocyte stimulating hormone antibody;Beta MSH antibody;Beta-LPH antibody;Beta-MSH antibody;CLIP antibody;COLI_HUMAN antibody;Corticotropin like intermediary peptide antibody;Corticotropin lipotropin antibody;Corticotropin-lipotropin antibody;Gamma MSH antibody;Gamma-LPH antibody;Gamma-MSH antibody;Lipotropin beta antibody;Lipotropin gamma antibody;LPH antibody;Melanotropin alpha antibody;Melanotropin antibody;Melanotropin beta antibody;Melanotropin gamma antibody;met enkephalin antibody;Met-enkephalin antibody;MSH antibody;NPP antibody;POC antibody;POMC antibody;pro ACTH endorphin antibody;Proopiomelanocortin antibody;Proopiomelanocortin preproprotein antibody

SUBCELLULAR LOCATION

Secreted.

FUNCTION

Pro-opiomelanocortin (POMC) is a precursor polypeptide with 241 amino acid residues. POMC is synthesized in corticotrophs of the anterior pituitary from the 267-amino-acid-long polypeptide precursor pre-pro-opiomelanocortin (pre-POMC), by the removal of a 26-amino-acid-long signal peptide sequence during translation. POMC is part of the central melanocortin system. This gene encodes a preproprotein that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the preproprotein and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. The antimicrobial melanotropin alpha peptide exhibits antibacterial and antifungal activity. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described.