DFNA5/GSDME Rabbit Polyclonal Antibody (ER1901-12)

UNIPROT #

O60443

PROTEIN NAME

DFNA5/GSDME

SYNONYMS

2310037D07Rik antibody;4932441K13Rik antibody;Deafness, autosomal dominant 5 antibody;Deafness, autosomal dominant 5 protein antibody;DFNA5 antibody;DFNA5 gene antibody;DFNA5_HUMAN antibody;Dfna5h antibody;EG14210 antibody;Fin15 antibody;ICERE 1 antibody;ICERE-1 antibody;Inversely correlated with estrogen receptor expression 1 antibody;Non-syndromic hearing impairment protein 5 antibody;Nonsyndromic hearing impairment protein antibody

SEQUENCE SIMILARITIES

Belongs to the gasdermin family.

TISSUE SPECIFICITY

Expressed in cochlea. Low level of expression in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas, with highest expression in placenta.

POST-TRANSLATIONAL MODIFICATION

Cleavage at Asp-270 by CASP3 (mature and uncleaved precursor forms) relieves autoinhibition and is sufficient to initiate pyroptosis.

SUBCELLULAR LOCATION

Cell membrane, Cytoplasm, cytosol.

FUNCTION

Plays a role in the TP53-regulated cellular response to DNA damage probably by cooperating with TP53. Gasdermin-E, N-terminal: Switches CASP3-mediated apoptosis induced by TNF or danger signals, such as chemotherapy drugs, to pyroptosis. Produced by the cleavage of GSDME by CASP3, perforates cell membrane and thereby induces pyroptosis. After cleavage, moves to the plasma membrane where it strongly binds to inner leaflet lipids, bisphosphorylated phosphatidylinositols, such as phosphatidylinositol (4,5)-bisphosphate. Mediates secondary necrosis downstream of the mitochondrial apoptotic pathway and CASP3 activation as well as in response to viral agents. Exhibits bactericidal activity.