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KCNQ4 Rabbit Polyclonal Antibody (ER2001-23)

Price: Regular price $315.00

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Catalog# ER2001-23

Rabbit Polyclonal to KCNQ4

Tested for

  • WB

  • IF-Cell

  • IHC-P

  • FC

Reacts with

  • Human

  • Mouse

  • Rat

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Specifications

Product Type

Rabbit polyclonal primary

Product Name

KCNQ4 Rabbit Polyclonal Antibody (ER2001-23)

Immunogen

Synthetic peptide within mouse kcnq4 aa 580-640.

Host

Rabbit

Positive Control

Rat kidney tissue lysates, 293T, rat smooth muscle tissue, mouse brain tissue, K562.

Conjugation

Unconjugated

Clonality

Polyclonal

RRID

AB_3069502

APPLICATION DILUTION

  • WB

  • 1:500-1:2,000

  • IF-Cell

  • 1:50-1:200

  • IHC-P

  • 1:50-1:200

  • FC

  • 1:50-1:100

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1ug/ul

Purification

Immunogen affinity purified.

Molecular Weight

77kDa

Isotype

IgG

TARGET

UNIPROT #

P56696

PROTEIN NAME

KCNQ4

SYNONYMS

DFNA 2 antibody;DFNA2 antibody;KCNQ 4 antibody;Kcnq4 antibody;KCNQ4_HUMAN antibody;KQT like 4 antibody;KQT-like 4 antibody;KV7.4 antibody;Potassium channel KQT like 4 antibody;Potassium channel subunit alpha KvLQT4 antibody;Potassium voltage gated channel KQT like protein 4 antibody;Potassium voltage gated channel KQT like subfamily member 4 antibody;Potassium voltage gated channel subfamily KQT member 4 antibody;Potassium voltage-gated channel subfamily KQT member 4 antibody;Voltage gated potassium channel subunit Kv7.4 antibody;Voltage-gated potassium channel subunit Kv7.4 antibody

SUBCELLULAR LOCATION

Cell membrane, Membrane.

FUNCTION

Probably important in the regulation of neuronal excitability. May underlie a potassium current involved in regulating the excitability of sensory cells of the cochlea. KCNQ4 channels are blocked by linopirdin, XE991 and bepridil, whereas clofilium is without significant effect. Muscarinic agonist oxotremorine-M strongly suppress KCNQ4 current in CHO cells in which cloned KCNQ4 channels were coexpressed with M1 muscarinic receptors. Mutagenesis experiments were carried out by expressing in Xenopus oocytes KCNQ4 mutants either individually (homomultimers) or in combination with wild-type KCNQ4 (mut/wt homomultimers) in a ratio of 1:1, to mimic the situation in a heterozygous DFNA2 patient.

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