Phospho-SHP2 (Y542) Recombinant Rabbit Monoclonal Antibody [SN61-01] (ET1611-22)

UNIPROT #

Q06124

PROTEIN NAME

Phospho-SHP2 (Y542)

SYNONYMS

BPTP3 antibody;CFC antibody;JMML antibody;METCDS antibody;MGC14433 antibody;NS1 antibody;OTTHUMP00000166107 antibody;OTTHUMP00000166108 antibody;Protein tyrosine phosphatase 2 antibody;Protein tyrosine phosphatase 2C antibody;Protein tyrosine phosphatase non receptor type 11 antibody;Protein-tyrosine phosphatase 1D antibody;Protein-tyrosine phosphatase 2C antibody;PTN11_HUMAN antibody;PTP-1D antibody;PTP-2C antibody;PTP1D antibody;PTP2C antibody;PTPN11 antibody;SAP2 antibody;SH-PTP2 antibody;SH-PTP3 antibody;SH2 domain containing protein tyrosine phosphatase 2 antibody;SHP 2 antibody;SHP-2 antibody;Shp2 antibody;SHPTP2 antibody;SHPTP3 antibody;Syp antibody;Tyrosine-protein phosphatase non-receptor type 11 antibody

SEQUENCE SIMILARITIES

Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily.

TISSUE SPECIFICITY

Widely expressed, with highest levels in heart, brain, and skeletal muscle.

POST-TRANSLATIONAL MODIFICATION

Phosphorylated on Tyr-542 and Tyr-580 upon receptor protein tyrosine kinase activation; which creates a binding site for GRB2 and other SH2-containing proteins. Phosphorylated upon activation of the receptor-type kinase FLT3. Phosphorylated upon activation of the receptor-type kinase PDGFRA (By similarity). Phosphorylated by activated PDGFRB.

SUBCELLULAR LOCATION

Cytoplasm, Nucleus.

FUNCTION

Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) also known as protein-tyrosine phosphatase 1D (PTP-1D), Src homology region 2 domain-containing phosphatase-2 (SHP-2), or protein-tyrosine phosphatase 2C (PTP-2C) is an enzyme that in humans is encoded by the PTPN11 gene. PTPN11 is a protein tyrosine phosphatase (PTP) Shp2. PTPN11 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia.