TMPRSS2 Rabbit Polyclonal Antibody (HA500060)

UNIPROT #

O15393

PROTEIN NAME

TMPRSS2

SYNONYMS

D16Ertd61e;Epitheliasin;FLJ41954;MGC6821;PP9284;PRSS10;Serine protease 10;TMPRSS2;TMPRSS2 ERG FUSION GENE, INCLUDED;TMPRSS2 ETV1 FUSION GENE, INCLUDED;TMPS2_HUMAN;Transmembrane protease serine 2 catalytic chain;Transmembrane protease, serine 2;Transmembrane protease, serine 2, EC 3.4.219

SUBCELLULAR LOCATION

Cell membrane, Membrane, Secreted.

FUNCTION

Plasma membrane-anchored serine protease that participates in proteolytic cascades of relevance for the normal physiologic function of the prostate . Androgen-induced TMPRSS2 activates several substrates that include pro-hepatocyte growth factor/HGF, the protease activated receptor-2/F2RL1 or matriptase/ST14 leading to extracellular matrix disruption and metastasis of prostate cancer cells . In addition, activates trigeminal neurons and contribute to both spontaneous pain and mechanical allodynia (By similarity).By similarity3 Publications(Microbial infection) Facilitates human coronaviruses SARS-CoV and SARS-CoV-2 infections via two independent mechanisms, proteolytic cleavage of ACE2 receptor which promotes viral uptake, and cleavage of coronavirus spike glycoproteins which activates the glycoprotein for host cell entry . Proteolytically cleaves and activates the spike glycoproteins of human coronavirus 229E (HCoV-229E) and human coronavirus EMC (HCoV-EMC) and the fusion glycoproteins F0 of Sendai virus (SeV), human metapneumovirus (HMPV), human parainfluenza 1, 2, 3, 4a and 4b viruses (HPIV). Essential for spread and pathogenesis of influenza A virus (strains H1N1, H3N2 and H7N9); involved in proteolytic cleavage and activation of hemagglutinin (HA) protein which is essential for viral infectivity.