TRPML3 Rabbit Polyclonal Antibody (ER1901-21)

UNIPROT #

Q8TDD5

PROTEIN NAME

TRPML3

SYNONYMS

MCOLN 3 antibody;MCOLN3 antibody;FLJ11006 antibody;FLJ36629 antibody;MCLN3_HUMAN antibody;Mcoln3 antibody;MGC71509 antibody;Mucolipin 3 antibody;Mucolipin-3 antibody;TRP ML3 antibody;TRPML3 antibody

SEQUENCE SIMILARITIES

Belongs to the transient receptor (TC 1.A.4) family. Polycystin subfamily. MCOLN3 sub-subfamily.

POST-TRANSLATIONAL MODIFICATION

N-glycosylated.

SUBCELLULAR LOCATION

Early endosome membran, late endosome membrane, stereocilium membrane, autophagosome membrane.

FUNCTION

Nonselective ligand-gated cation channel probably playing a role in the regulation of membrane trafficking events. Acts as Ca2+-permeable cation channel with inwardly rectifying activity. Mediates release of Ca2+ from endosomes to the cytoplasm, contributes to endosomal acidification and is involved in the regulation of membrane trafficking and fusion in the endosomal pathway (By similarity). Does not seem to act as mechanosensory transduction channel in inner ear sensory hair cells. Proposed to play a critical role at the cochlear stereocilia ankle-link region during hair-bundle growth. Involved in the regulation of autophagy. Through association with GABARAPL2 may be involved in autophagosome formation possibly providing Ca2+ for the fusion process. Through a possible and probably tissue-specific heteromerization with MCOLN1 may be at least in part involved in many lysosome-dependent cellular events. Possible heteromeric ion channel assemblies with TRPV5 show pharmacological similarity with TRPML3 (By similarity).