ALDH1A1 Rabbit Polyclonal Antibody (R1706-2)

UNIPROT #

P00352

PROTEIN NAME

ALDH1A1

SYNONYMS

Acetaldehyde dehydrogenase 1 antibody;AHD2 antibody;AL1A1_HUMAN antibody;ALDC antibody;Aldehyde dehydrogenase 1 family member A1 antibody;Aldehyde dehydrogenase 1 soluble antibody;Aldehyde dehydrogenase 1A1 antibody;Aldehyde dehydrogenase antibody;Aldehyde dehydrogenase cytosolic antibody;Aldehyde dehydrogenase family 1 member A1 antibody;Aldehyde dehydrogenase liver cytosolic antibody;ALDH 1 antibody;ALDH 1A1 antibody;ALDH class 1 antibody;ALDH, liver cytosolic antibody;ALDH-E1 antibody;ALDH1 A1 antibody;ALDH1 antibody;ALDH11 antibody;ALDH1A1 antibody;ALHDII antibody;cytosolic antibody;epididymis luminal protein 12 antibody;epididymis luminal protein 9 antibody;epididymis secretory sperm binding protein Li 53e antibody;HEL-S-53e antibody;MGC2318 antibody;PUMB1 antibody;RALDH 1 antibody;RalDH1 antibody;Retinal dehydrogenase 1 antibody

SEQUENCE SIMILARITIES

Belongs to the aldehyde dehydrogenase family.

POST-TRANSLATIONAL MODIFICATION

The N-terminus is blocked most probably by acetylation.

SUBCELLULAR LOCATION

Cytoplasm.

FUNCTION

Aldehyde dehydrogenases (ALDHs) mediate NADP+-dependent oxidation of aldehydes into acids during the detoxification of alcohol-derived acetaldehyde; metabolism of corticosteroids, biogenic amines and neurotransmitters; and lipid peroxidation. ALDH1A1, also designated retinal dehydrogenase 1 (RalDH1 or RALDH1), aldehyde dehydrogenase family 1 member A1, aldehyde dehydrogenase cytosolic, ALDHII, ALDH-E1 or ALDH E1, is a retinal dehydrogenase that participates in the biosynthesis of retinoic acid (RA). There are two major liver isoforms of ALDH1 that can localize to cytosolic or mitochondrial space. The ALDH1A2 (RALDH2, RALDH2-T) gene produces three different transcripts and also catalyzes the synthesis of RA from retinaldehyde. ALDH1A3 (ALDH6, RALDH3, ALDH1A6) is a 37 kb gene that consists of 13 exons and produces a major transcript of approximately 3.5 kb most abundant in salivary gland, stomach and kidney. ALDH3A1 (stomach type, ALDH3, ALDHIII) forms a cytoplasmic homodimer that preferentially oxidizes aromatic aldehyde substrates. ALDH genes upregulate as a part of the oxidative stress response, and appear to be abundant in certain tumors that have an accelerated metabolism toward chemotherapy agents.