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COMT Recombinant Rabbit Monoclonal Antibody [JG39-48] (ET7108-89)

Price: Regular price $385.00

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Catalog# ET7108-89

Rabbit Monoclonal to COMT

Tested for

  • WB

  • IHC-P

Reacts with

  • Human

  • Mouse

  • Rat

Recombinant production enables lot-to-lot consistency and is animal-cruelty-free

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Specifications

Product Type

Recombinant Rabbit monoclonal primary

Product Name

COMT Recombinant Rabbit Monoclonal Antibody [JG39-48] (ET7108-89)

Immunogen

Recombinant protein within comt aa 11-107 / 271.

Host

Rabbit

Positive Control

MCF-7, rat testis tissue lysate, mouse testis tissue.

Conjugation

Unconjugated

Clonality

Monoclonal

Clone Number

JG39-48

RRID

AB_3070882

APPLICATION DILUTION

  • WB

  • 1:500-1:2,000

  • IHC-P

  • 1:50-1:100

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1ug/ul

Purification

Protein A affinity purified.

Molecular Weight

24 kDa

Isotype

IgG

TARGET

UNIPROT #

P21964

PROTEIN NAME

COMT

SYNONYMS

Catechol O methyltransferase antibody;Catechol O-methyltransferase antibody;COMT antibody;COMT_HUMAN antibody;EC 2.1.1.6 antibody

SEQUENCE SIMILARITIES

Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.

TISSUE SPECIFICITY

Brain, liver, placenta, lymphocytes and erythrocytes.

POST-TRANSLATIONAL MODIFICATION

The N-terminus is blocked.

SUBCELLULAR LOCATION

Cell membrane. Cytoplasm.

FUNCTION

Catechol-O-methyltransferase (COMT) plays a crucial role in the regulation of central dopaminergic systems by catalyzing the inactivation of catechol-amines. It is widely distributed in most tissues in soluble and membrane-bound forms. COMT-mediated methylation metabolism of catecholamine neurotransmitters is a first-line detoxification pathway. A Val158Met polymorphism of the COMT gene affects activity of the enzyme and influences performance and efficiency of the prefrontal cortex of the brain. Sequential conversion of estradiol to methoxyestradiol by COMT, contributes to the antimitogenic effects of estradiol on vascular smooth muscle cell growth via estrogen receptor-independent mechanisms.

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