VCP Rabbit Polyclonal Antibody (ER30603)

UNIPROT #

P55072

PROTEIN NAME

VCP

SYNONYMS

15S Mg(2+) ATPase p97 subunit antibody;15S Mg(2+)-ATPase p97 subunit antibody;ALS14 antibody;ATPase p97 antibody;CDC48 antibody;IBMPFD antibody;MGC131997 antibody;MGC148092 antibody;MGC8560 antibody;p97 antibody;TER ATPase antibody;TERA antibody;TERA_HUMAN antibody;Transitional endoplasmic reticulum ATPase antibody;Valosin containing protein antibody;Valosin-containing protein antibody;VCP antibody;Yeast Cdc48p homolog antibody

SEQUENCE SIMILARITIES

Belongs to the AAA ATPase family.

POST-TRANSLATIONAL MODIFICATION

Phosphorylated by tyrosine kinases in response to T-cell antigen receptor activation. Phosphorylated in mitotic cells.; ISGylated.; Methylation at Lys-315 catalyzed by VCPKMT is increased in the presence of ASPSCR1. Lys-315 methylation may decrease ATPase activity.

SUBCELLULAR LOCATION

Cytoplasm, nucleus, endoplasmic reticulum

FUNCTION

Valosin-containing protein (VCP) is a highly conserved, that belongs to the AAA (ATPase associated with a variety of cellular activities) family of proteins. It is necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. VCP is involved in the formation of the transitional endoplasmic reticulum (tER). VCP homo-hexamers associate with a variety of protein cofactors to form many distinct protein complexes, which act as chaperones to unfold proteins and transport them to specific cellular compartments or to the proteosome.