CLPX Recombinant Rabbit Monoclonal Antibody [JE62-96] (HA721016)

UNIPROT #

O76031

PROTEIN NAME

CLPX

SYNONYMS

ATP dependent Clp protease ATP binding subunit clpX like, mitochondrial antibody;ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial antibody;AU014732 antibody;Caseinolytic mitochondrial matrix peptidase chaperone subunit antibody;Caseinolytic peptidase X (E.coli) antibody;Caseinolytic protease X antibody;clpX antibody;ClpX caseinolytic peptidase X homolog antibody;ClpX caseinolytic protease X homolog antibody;CLPX_HUMAN antibody;E330029I21 antibody;Energy dependent regulator of proteolysis antibody

SUBCELLULAR LOCATION

Mitochondrion, mitochondrion nucleoid.

FUNCTION

ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial is an enzyme that in humans is encoded by the CLPX gene. This protein is a member of the family of AAA Proteins (AAA+ ATPase) and is to form the protein complex of Clp protease. ClpX is an ATP-dependent chaperone that can recognize protein substrates by binding to protein degradation tags. These tags can be short unstructured peptide sequences (e.g., ssrA-tag in E coli). As an essential component of ClpP protease complex, ClpX recruits degradable substrates and unfolds their tertiary structure, which requires energy provided by ATP hydrolysis. Subsequently, these ClpX Chaperones transfer protein substrates into the proteolytic chamber formed by ClpP tetradecamer. In mammals, ClpXP protease is a pivotal contributor to mitochondrial protein quality control. A compromised ClpXP function usually leads to the accumulation of damaged proteins and mitochondrial dysfunctions, which believes to be potential causes for neurodegenerative diseases and aging.