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Nucleolin Recombinant Rabbit Monoclonal Antibody [JE65-71] (HA721073)

Price: Regular price $385.00

Volume

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Catalog# HA721073

Rabbit Monoclonal to Nucleolin

Tested for

  • WB

  • IF-Cell

  • IHC-P

Reacts with

  • Human

  • Mouse

  • Rat

Recombinant production enables lot-to-lot consistency and is animal-cruelty-free

Safety datasheet

Select your chosen country/region

Specifications

Product Type

Recombinant Rabbit monoclonal primary

Product Name

Nucleolin Recombinant Rabbit Monoclonal Antibody [JE65-71] (HA721073)

Immunogen

Synthetic peptide within human csde1 aa 661-710/710.

Host

Rabbit

Positive Control

K562 cell lysate, Jurkat cell lysate, Hela cell lysate, A431 cell lysate, Hela, rat bladder tissue, human lung tissue, human thyroid tissue, human colon carcinoma tissue, human skin tissue, human spleen tissue, human breast carcinoma tissue, human esophagus tissue, human placenta tissue, mouse liver tissue, MEF cell lysate, NIH/3T3 cell lysate, SiHa.

Conjugation

Unconjugated

Clonality

Monoclonal

Clone Number

JE65-71

RRID

AB_3072197

APPLICATION DILUTION

  • WB

  • 1:500-1:5,000

  • IF-Cell

  • 1:200

  • IHC-P

  • 1:200-1:400

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1ug/ul

Purification

Protein A affinity purified.

Molecular Weight

Predicted band size: 77 kDa

Isotype

IgG

TARGET

UNIPROT #

P19338

PROTEIN NAME

Nucleolin

SYNONYMS

C23 antibody;FLJ45706 antibody;MS1116 antibody;NCL antibody;Nucl antibody;NUCL_HUMAN antibody;Nucleolin antibody;Protein C23 antibody

SUBCELLULAR LOCATION

Cytoplasm, nucleolus.

FUNCTION

Nucleolin is a protein that in humans is encoded by the NCL gene. Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. Midkine and pleiotrophin bind to cell-surface nucleolin as a low affinity receptor. This binding can inhibit HIV infection. Nucleolin at the cell surface is the receptor for the Respiratory Syncytial Virus (RSV) fusion protein. Interference with the nucleolin - RSV fusion protein interaction has been shown to be therapeutic against RSV infection in cell cultures and animal models.

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