Phospho-alpha Synuclein (S129) Recombinant Rabbit Monoclonal Antibody [JB22-44] (ET7107-30)

UNIPROT #

P37840

PROTEIN NAME

Phospho-alpha Synuclein (S129)

SYNONYMS

Alpha synuclein antibody;Alpha-synuclein antibody;Alpha-synuclein, isoform NACP140 antibody;alphaSYN antibody;MGC105443 antibody;MGC110988 antibody;MGC127560 antibody;MGC64356 antibody;NACP antibody;Non A beta component of AD amyloid antibody;Non A4 component of amyloid antibody;Non A4 component of amyloid precursor antibody;Non-A beta component of AD amyloid antibody;Non-A-beta component of alzheimers disease amyloid , precursor of antibody;Non-A4 component of amyloid precursor antibody;Non-A4 component of amyloid, precursor of antibody;OTTHUMP00000218549 antibody;OTTHUMP00000218551 antibody;OTTHUMP00000218552 antibody;OTTHUMP00000218553 antibody;OTTHUMP00000218554 antibody;PARK 1 antibody;PARK 4 antibody;PARK1 antibody;PARK4 antibody;Parkinson disease (autosomal dominant, Lewy body) 4 antibody;Parkinson disease familial 1 antibody;SNCA antibody;Snca synuclein, alpha (non A4 component of amyloid precursor) antibody;SYN antibody;Synuclein alpha antibody;Synuclein alpha 140 antibody;Synuclein, alpha (non A4 component of amyloid precursor) antibody;SYUA_HUMAN antibody

SEQUENCE SIMILARITIES

Belongs to the synuclein family.

TISSUE SPECIFICITY

Highly expressed in presynaptic terminals in the central nervous system. Expressed principally in brain.

POST-TRANSLATIONAL MODIFICATION

Phosphorylated, predominantly on serine residues. Phosphorylation by CK1 appears to occur on residues distinct from the residue phosphorylated by other kinases. Phosphorylation of Ser-129 is selective and extensive in synucleinopathy lesions. In vitro, phosphorylation at Ser-129 promoted insoluble fibril formation. Phosphorylated on Tyr-125 by a PTK2B-dependent pathway upon osmotic stress.; Hallmark lesions of neurodegenerative synucleinopathies contain alpha-synuclein that is modified by nitration of tyrosine residues and possibly by dityrosine cross-linking to generated stable oligomers.; Ubiquitinated. The predominant conjugate is the diubiquitinated form (By similarity).; Acetylation at Met-1 seems to be important for proper folding and native oligomeric structure.

SUBCELLULAR LOCATION

Nucleus. Cytosol. Secreted. Membrane.

FUNCTION

Alpha-synuclein is a protein that, in humans, is encoded by the SNCA gene. Alpha-synuclein is a neuronal protein that regulates synaptic vesicle trafficking and subsequent neurotransmitter release. It is abundant in the brain, while smaller amounts are found in the heart, muscle and other tissues. In the brain, alpha-synuclein is found mainly in the axon terminals of presynaptic neurons. Within these terminals, alpha-synuclein interacts with phospholipids and proteins. Presynaptic terminals release chemical messengers, called neurotransmitters, from compartments known as synaptic vesicles. The release of neurotransmitters relays signals between neurons and is critical for normal brain function. The human alpha-synuclein protein is made of 140 amino acids. An alpha-synuclein fragment, known as the non-Abeta component (NAC) of Alzheimer's disease amyloid, originally found in an amyloid-enriched fraction, was shown to be a fragment of its precursor protein, NACP. It was later determined that NACP was the human homologue of Torpedo synuclein. Therefore, NACP is now referred to as human alpha-synuclein.