Phospho-PKC alpha (T638) Recombinant Rabbit Monoclonal Antibody [JF0964] (ET1702-17)

UNIPROT #

P17252

PROTEIN NAME

Phospho-PKC alpha (T638)

SYNONYMS

AAG6 antibody;Aging associated gene 6 antibody;aPKC antibody;KPCA_HUMAN antibody;PKC alpha antibody;PKC-A antibody;PKC-alpha antibody;PKCA antibody;PRKACA antibody;PRKCA antibody;Protein Kinase C alpha antibody;Protein kinase C alpha type antibody

SEQUENCE SIMILARITIES

Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.

SUBCELLULAR LOCATION

Cytoplasm, Cell membrane, Mitochondrion membrane, Nucleus.

FUNCTION

Members of the protein kinase C (PKC) family play a key regulatory role in a variety of cellular functions including cell growth and differentiation, gene expression, hormone secretion and membrane function. PKCs were originally identified as serine/threonine protein kinases whose activity was dependent on calcium and phospholipids. Diacylglycerols (DAG) and tumor-promoting phorbol esters bind to and activate PKC. PKCs can be subdivided into many different isoforms (α, βI, βII, γ, δ, ε, ζ, η, θ, λ/ι, μ and ν). Patterns of expression for each PKC isoform differ among tissues and PKC family members exhibit clear differences in their cofactor dependencies. For instance, the kinase activities of PKC δ and ε are independent of Ca²⁺. On the other hand, most of the other PKC members possess phorbol ester-binding activities and kinase activities.