HRP Conjugated c-Myc Rabbit Polyclonal Antibody (0912-4)

UNIPROT #

P01106

PROTEIN NAME

c-Myc

SYNONYMS

AU016757 antibody;Avian myelocytomatosis viral oncogene homolog antibody;bHLHe39 antibody;c Myc antibody;Class E basic helix-loop-helix protein 39 antibody;MRTL antibody;Myc antibody;Myc protein antibody;Myc proto oncogene protein antibody;Myc proto-oncogene protein antibody;myc-related translation/localization regulatory factor antibody;MYC_HUMAN antibody;Myc2 antibody;MYCC antibody;Myelocytomatosis oncogene antibody;Niard antibody;Nird antibody;Oncogene Myc antibody;OTTHUMP00000158589 antibody;Proto-oncogene c-Myc antibody;Protooncogene homologous to myelocytomatosis virus antibody;RNCMYC antibody;Transcription factor p64 antibody;Transcriptional regulator Myc-A antibody;V-Myc avian myelocytomatosis viral oncogene homolog antibody;v-myc myelocytomatosis viral oncogene homolog (avian) antibody

POST-TRANSLATIONAL MODIFICATION

Phosphorylated by PRKDC. Phosphorylation at Ser-329 by PIM2 leads to the stabilization of MYC (By similarity). Phosphorylation at Ser-62 by CDK2 prevents Ras-induced senescence. Phosphorylated at Ser-62 by DYRK2; this primes the protein for subsequent phosphorylation by GSK3B at Thr-58. Phosphorylation at Thr-58 and Ser-62 by GSK3 is required for ubiquitination and degradation by the proteasome.; Ubiquitinated by the SCF(FBXW7) complex when phosphorylated at Thr-58 and Ser-62, leading to its degradation by the proteasome. In the nucleoplasm, ubiquitination is counteracted by USP28, which interacts with isoform 1 of FBXW7 (FBW7alpha), leading to its deubiquitination and preventing degradation. In the nucleolus, however, ubiquitination is not counteracted by USP28 but by USP36, due to the lack of interaction between isoform 3 of FBXW7 (FBW7gamma) and USP28, explaining the selective MYC degradation in the nucleolus. Also polyubiquitinated by the DCX(TRUSS) complex. Ubiquitinated by TRIM6 in a phosphorylation-independent manner (By similarity).

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

Myc gene encodes for a transcription factor that is believed to regulate expression of 15% of all genes through binding on Enhancer Box sequences (E-boxes) and recruiting histone acetyltransferases (HATs). c-Myc is commonly activated in a variety of tumor cells and plays an important role in cellular proliferation, differentiation, apoptosis and cell cycle progression. This c-Myc antibody detects endogenous levels of total c-Myc protein and is also for detection of Myc-tagged fusion proteins.