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BMP2 Rabbit Polyclonal Antibody (ER80602)

Price: Regular price $315.00

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Catalog# ER80602

Rabbit Polyclonal to BMP2

Tested for

  • WB

  • IF-Cell

  • IHC-P

  • FC

Reacts with

  • Human

  • Mouse

  • Rat

This product has been cited in peer reviewed publications, see list HERE

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Specifications

Product Type

Rabbit polyclonal primary

Product Name

BMP2 Rabbit Polyclonal Antibody (ER80602)

Immunogen

Synthetic peptide within human bmp2 aa 51-100.

Host

Rabbit

Positive Control

Caco-2 cell lysate, C2C12 cell lysate, Hela, MCF-7, rat small intestine tissue, human breast cancer tissue, mouse small intestine tissue.

Conjugation

Unconjugated

Clonality

Polyclonal

RRID

AB_3069591

APPLICATION DILUTION

  • WB

  • 1:1,000

  • IF-Cell

  • 1:200

  • IHC-P

  • 1:200

  • FC

  • 1:100-1:200

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1ug/ul

Purification

Immunogen affinity purified.

Molecular Weight

Predicted band size: 45 kDa

Isotype

IgG

TARGET

UNIPROT #

P12643

PROTEIN NAME

BMP2

SYNONYMS

BDA2 antibody;BMP-2 antibody;BMP-2A antibody;Bmp2 antibody;BMP2_HUMAN antibody;BMP2A antibody;Bone morphogenetic protein 2 antibody;Bone morphogenetic protein 2A antibody

SEQUENCE SIMILARITIES

Belongs to the TGF-beta family.

TISSUE SPECIFICITY

Particularly abundant in lung, spleen and colon and in low but significant levels in heart, brain, placenta, liver, skeletal muscle, kidney, pancreas, prostate, ovary and small intestine.

SUBCELLULAR LOCATION

Secreted.

FUNCTION

BMP-2 belongs to the TGF-β superfamily of proteins. BMP-2 plays an important role in the development of bone and cartilage. It is involved in the hedgehog pathway, TGF beta signaling pathway, and in cytokine-cytokine receptor interaction. It is involved also in cardiac cell differentiation and epithelial to mesenchymal transition. Implantation of BMP-2 in a collagen sponge induces new bone formation and can be used for the treatment of bony defects, delayed union, and non-union.

CITATIONS

  • Potential use of 3D-printed graphene oxide scafold for construction of the cartilage layer

  • Li Kehan,et al

    Hippo/YAP1 promotes osteoporotic mice bone defect repair via the activating of Wnt signaling pathway

  • Xiangjin LinQi Bao

    Continuous release of bone morphogenetic protein-2 through nano-graphene oxide-based delivery influences the activation of the NF-κB signal transduction pathway

  • Intermittent parathyroid hormone promotes cementogenesis in a PKA- and ERK1/2-dependent manner

  • Huang, L., Yin, X., Chen, J., Liu, R., Xiao, X., Hu, Z., He, Y., & Zou, S.

    Lithium chloride promotes osteogenesis and suppresses apoptosis during orthodontic tooth movement in osteoporotic model via regulating autophagy. Bioactive materials, 6(10), 3074–3084.

  • Ming Zhang,Kangshou Yao

    Proteomic Analyses Reveal Common Promiscuous Patterns of Cell Surface Proteins on Human Embryonic Stem Cells and Sperms

  • Li Zhuhai,et al

    Tetrahedral framework nucleic acids‐based delivery of microRNA‐155 alleviates intervertebral disc degeneration through targeting Bcl‐2/Bax apoptosis pathway

  • Xue-Xue Zhu,et al

    Nesfatin-1 enhances vascular smooth muscle calcification through facilitating BMP-2 osteogenic signaling

  • Ming Zhang

    Global Expression of Cell Surface Proteins in Embryonic Stem Cells

  • Yu Jin,et al

    A Rat Model for Microimplant-assisted Rapid Palatal Expansion

  • Huang Jie,et al

    DP7-C/mir-26a system promotes bone regeneration by remodeling the osteogenic immune microenvironment

  • Du Qianxin,et al

    Beta-adrenergic receptor antagonist propranolol prevents bisphosphonate-related osteonecrosis of the jaw by promoting osteogenesis

  • A novel porous hydroxyapatite scaffold (pHAMG) enhances angiogenesis and osteogenesis around dental implants by regulating the immune microenvironment

  • Bone marrow mesenchymal stem cell-derived exosomes loaded with miR-26a through the novel immunomodulatory peptide DP7-C can promote osteogenesis

  • Wanshun Wang,et al

    Microenvironment-responsive injectable hydrogel for neuro-vascularized bone regeneration

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