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CDKN2A/p16INK4a Rabbit Polyclonal Antibody (ER2001-30)

Price: Regular price $315.00

Volume

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Catalog# ER2001-30

Rabbit Polyclonal to CDKN2A/p16INK4a

Tested for

  • WB

  • IHC-P

  • IF-Cell

  • FC

Reacts with

  • Human

  • Mouse

This product has been cited in peer reviewed publications, see list HERE

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Specifications

Product Type

Rabbit polyclonal primary

Product Name

CDKN2A/p16INK4a Rabbit Polyclonal Antibody (ER2001-30)

Immunogen

Recombinant protein within human aa dkn2a 1-200.

Host

Rabbit

Positive Control

Mouse brain tissue lysates, JAR, MCF-7, mouse placenta tissue, mouse colon tissue, mouse brain tissue, 293.

Conjugation

Unconjugated

Clonality

Polyclonal

RRID

AB_3069508

APPLICATION DILUTION

  • WB

  • 1:500-1:2,000

  • IHC-P

  • 1:50-1:200

  • IF-Cell:1:50-1:200

  • FC

  • 1:50-1:100

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*TBS (pH7.4), 1% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1ug/ul

Purification

Immunogen affinity purified.

Molecular Weight

17 kDa

Isotype

IgG

TARGET

UNIPROT #

P42771

PROTEIN NAME

CDKN2A/p16INK4a

SYNONYMS

CCM2 antibody;CDK4 inhibitor p16 INK4 antibody;CDK4I antibody;CDKN2 antibody;CDKN2A antibody;Cell cycle negative regulator beta antibody;CMM2 antibody;Cyclin dependent kinase 4 inhibitor A antibody;Cyclin dependent kinase inhibitor 2A (melanoma p16 inhibits CDK4) antibody;Cyclin Dependent Kinase Inhibitor 2A antibody;Cyclin dependent kinase inhibitor 2A isoform 4 antibody;Cyclin dependent kinase inhibitor 2A isoforms 1/2/3 antibody;Cyclin dependent kinase inhibitor p16 antibody;INK4 antibody;INK4A antibody;MLM antibody;MTS1 antibody;Multiple tumor suppressor 1 antibody;p14 antibody;p16 antibody;P16INK4 antibody;p16INK4a antibody;p19 antibody;p19Arf antibody;TP16 antibody

SUBCELLULAR LOCATION

Cytoplasm, Nucleus.

FUNCTION

CDKN2A, also known as cyclin-dependent kinase inhibitor 2A, is a gene which in humans is located at chromosome 9, band p21.3. It is ubiquitously expressed in many tissues and cell types.The gene codes for two proteins, including the INK4 family member p16 (or p16INK4a) and p14arf. Both act as tumor suppressors by regulating the cell cycle. p16 inhibits cyclin dependent kinases 4 and 6 (CDK4 and CDK6) and thereby activates the retinoblastoma (Rb) family of proteins, which block traversal from G1 to S-phase. p14ARF (known as p19ARF in the mouse) activates the p53 tumor suppressor. Somatic mutations of CDKN2A are common in the majority of human cancers, with estimates that CDKN2A is the second most commonly inactivated gene in cancer after p53. Germline mutations of CDKN2A are associated with familial melanoma, glioblastoma and pancreatic cancer.The CDKN2A gene also contains one of 27 SNPs associated with increased risk of coronary artery disease.

CITATIONS

  • Wu Y, Chen L, Feng C, et al

    Antitumor effect of toosendanin on oral squamous cell carcinoma via suppression of p-STAT3

  • Lin Hao,et al

    Identification and functional characterization of differentially expressed circRNAs in high glucose treated endothelial cells: Construction of circRNA-miRNA-mRNA network

  • Yang, L., Wang, B., Guo, F., Huang, R., Liang, Y., Li, L., Tao, S., Yin, T., Fu, P., & Ma, L.

    FFAR4 improves the senescence of tubular epithelial cells by AMPK/SirT3 signaling in acute kidney injury

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