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Chromogranin A Rabbit Polyclonal Antibody (ER40724)

Price: Regular price $315.00

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Catalog# ER40724

Rabbit Polyclonal to Chromogranin A

Tested for

  • WB

  • IHC-P

  • FC

  • IF-Tissue

  • IF-Cell

Reacts with

  • Human

  • Mouse

  • Rat

This product has been cited in peer reviewed publications, see list HERE

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Specifications

Product Type

Rabbit polyclonal primary

Product Name

Chromogranin A Rabbit Polyclonal Antibody (ER40724)

Immunogen

Synthetic peptide corresponding to c-terminal of mouse chromogranin a aa 408-457 / 457 (id: p10645).

Host

Rabbit

Positive Control

PC12 cell lysate, human pancreas tissue, mouse pancreas tissue, rat pancreas tissue, human colon cancer tissue, Lovo.

Conjugation

Unconjugated

Clonality

Polyclonal

RRID

AB_3069581

APPLICATION DILUTION

  • WB

  • 1:2,000

  • IHC-P

  • 1:200-1:1,000

  • FC

  • 1:100-1:200

  • IF-Tissue

  • 1:200

  • IF-Cell

  • 1:100

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1ug/ul

Purification

Immunogen affinity purified.

Molecular Weight

Predicted band size: 52 kDa

Isotype

IgG

TARGET

UNIPROT #

P10645

PROTEIN NAME

Chromogranin A

SYNONYMS

CISY_HUMAN antibody;Citrate synthase antibody;Citrate synthase, mitochondrial antibody;citrate synthetase antibody;Cs antibody;EC 2.3.3 antibody;EC 2.3.3.1 antibody

SEQUENCE SIMILARITIES

Belongs to the chromogranin/secretogranin protein family.

POST-TRANSLATIONAL MODIFICATION

CgA is O-glycosylated.

SUBCELLULAR LOCATION

Cytoplasmic vesicle, secreted.

FUNCTION

Chromogranin A is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is located in secretory vesicles of neurons and endocrine cells. Chromogranin A is the precursor to several functional peptides including vasostatin, pancreastatin, catestatin and parastatin. These peptides negatively modulate the neuroendocrine function of the releasing cell (autocrine) or nearby cells (paracrine). Chromogranin A might promote the generation of secretory granules. It is used as an indicator for pancreas and prostate cancer. It might play a role in early neoplasic progression. It is also elevated in diabetes.

CITATIONS

  • Li, B., Cheng, Y., Yin, Y., Xue, J., Yu, S., Gao, J., Liu, J., Zang, L., & Mu, Y.

    Reversion of early- and late-stage β-cell dedifferentiation by human umbilical cord-derived mesenchymal stem cells in type 2 diabetic mice

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