DLL4 Rabbit Polyclonal Antibody (ER1706-29)

UNIPROT #

Q9NR61

PROTEIN NAME

DLL4

SYNONYMS

AOS6 antibody;Delta 4 antibody;delta 4 precursor antibody;Delta ligand 4 antibody;delta ligand 4 precursor antibody;Delta like 4 antibody;Delta like 4 homolog antibody;Delta like 4 protein antibody;Delta like canonical Notch ligand 4 antibody;Delta like protein 4 antibody;Delta-like 4 (Drosophila) antibody;Delta-like protein 4 antibody;Delta4 antibody;DLL 4 antibody;Dll4 antibody;DLL4_HUMAN antibody;Drosophila Delta homolog 4 antibody;hdelta2 antibody;Homeobox protein DLL-4 antibody;MGC126344 antibody;Notch ligand delta 2 antibody;Notch ligand DLL4 antibody;Notch ligand DLL4 precursor antibody;XDLL-4 antibody

TISSUE SPECIFICITY

Expressed in vascular endothelium.

SUBCELLULAR LOCATION

Cell membrane.

FUNCTION

The LIN-12/Notch family of transmembrane receptors is believed to play a central role in development by regulating cell fate decisions. Notch proteins have been found to be overexpressed or rearranged in human tumors. Ligands for Notch include Jagged, Jagged-2 and Delta. While blocking the differentiation of progenitor cells into the B-cell lineage, Delta promotes the emergence of a population of cells with T cell/NK-cell characteristics. The protein is a membrane protein expressed in heart, pancreas, brain and muscle during gastrulation and early organogenesis and in adult heart and lung. Delta-4 is a membrane protein that activates Notch-1 and Notch-4. It is expressed in a wide range of adult and fetal tissues, especially in vascular endothelium.