Interferon alpha Rabbit Polyclonal Antibody (ER1802-4)

UNIPROT #

P01562

PROTEIN NAME

Interferon alpha

SYNONYMS

IFL antibody;IFN alpha antibody;IFN alpha 1/13 antibody;IFN alpha 1b antibody;IFN alphaD antibody;IFN antibody;IFN-alpha-1/13 antibody;IFNA@ antibody;IFNA1 antibody;IFNA1_HUMAN antibody;IFNA13 antibody;Interferon alpha 1 antibody;Interferon alpha-1/13 antibody;Interferon alpha-D antibody;Interferon alpha1 antibody;Interferon, alpha 13 antibody;LeIF D antibody

SEQUENCE SIMILARITIES

Belongs to the alpha/beta interferon family.

SUBCELLULAR LOCATION

Secreted.

FUNCTION

The genes encoding type I interferons (IFNs), which include 14 IFN-α genes (two of which are IFN-α1 and IFN-α13), one IFN-β gene, one IFN-w (also known as IFN-α II1) gene and a number of IFN-w pseudogenes, are clustered on human chromosome 9. IFN-α and -β are cytokines that are widely known to induce potent antiviral activity. They exert a variety of other biological effects, including antitumor and immunomodulatory activities and are increasingly used clinically to treat a range of malignancies, myelodysplasias and autoimmune diseases. IFN-w is antigenically different from human IFN-α, IFN-β or IFN-γ, but is a component of natural mixtures of IFN species produced by virus-induced leukocytes or Burkitt's lymphoma cells. The type I interferon receptor (IFN-αR) interacts with IFN-α, IFN-β and IFN-w, and seems to be a multisubunit receptor.