TNF Receptor II Recombinant Rabbit Monoclonal Antibody [JM113-01] (ET1703-63)

UNIPROT #

P20333

PROTEIN NAME

TNF Receptor II

SYNONYMS

CD120b antibody;p75 antibody;p75 TNF receptor antibody;p75TNFR antibody;p80 TNF alpha receptor antibody;p80 TNF-alpha receptor antibody;Soluble TNFR1B variant 1 antibody;TBP-2 antibody;TBPII antibody;TNF R II antibody;TNF R2 antibody;TNF R75 antibody;TNF-R2 antibody;TNF-RII antibody;TNFBR antibody;TNFR-II antibody;TNFR1B antibody;TNFR2 antibody;TNFR80 antibody;TNFRII antibody;Tnfrsf1b antibody;TNR1B_HUMAN antibody;Tumor necrosis factor beta receptor antibody;Tumor necrosis factor receptor 2 antibody;Tumor necrosis factor receptor superfamily member 1B antibody;Tumor necrosis factor receptor type II antibody;Tumor necrosis factor-binding protein 2 antibody

POST-TRANSLATIONAL MODIFICATION

Phosphorylated; mainly on serine residues and with a very low level on threonine residues.; A soluble form (tumor necrosis factor binding protein 2) is produced from the membrane form by proteolytic processing.

SUBCELLULAR LOCATION

Cell membrane, Membrane, Secreted.

FUNCTION

Tumor necrosis factor (TNF) is a pleiotropic cytokine whose function is mediated through two distinct cell surface receptors. These receptors, designated TNF-R1 and TNF-R2, are expressed on most cell types. The majority of TNF functions are primarily mediated through TNF-R1, while signaling through TNF-R2 occurs less extensively and is confined to cells of the immune system. Both of these proteins belong to the growing TNF and nerve growth factor (NGF) receptor superfamily, which includes FAS, CD30, CD27 and CD40. The members of this superfamily are type I membrane proteins that share sequence homology confined to the extracellular region. TNF-R1 shares a motif termed the "death domain" with FAS and three structurally unrelated signaling proteins, TRADD, FADD and RIP (1,3-8). This death domain is required for transduction of the apoptotic signal.