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CISH Rabbit Polyclonal Antibody (HA500505)

Price: Regular price $315.00

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Catalog# HA500505

Rabbit Polyclonal to CISH

Tested for

  • WB

  • IHC-P

  • ELISA

Reacts with

  • Human

  • Mouse

  • Rat

This product has been cited in peer reviewed publications, see list HERE

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Specifications

Product Type

Rabbit polyclonal primary

Product Name

CISH Rabbit Polyclonal Antibody (HA500505)

Immunogen

Synthetic peptide within human cish aa 209-258.

Host

Rabbit

Positive Control

Human kidney tissue lysate, Human tonsil tissue, Human breast cancer tissue.

Conjugation

Unconjugated

Clonality

Polyclonal

RRID

AB_3071590

APPLICATION DILUTION

  • WB

  • 1:200-1:1,000

  • IHC-P

  • 1:25-1:100

  • ELISA

  • 1:5,000-1:10,000

PROPERTIES

Form

Liquid

Storage Condition

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze/thaw cycles.

Storage Buffer

1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1ug/ul

Molecular Weight

Predicted band size: 29 kDa.

Isotype

IgG

TARGET

UNIPROT #

Q9NSE2

PROTEIN NAME

CISH

SYNONYMS

BACTS2 antibody;cis 1 antibody;CIS antibody;CIS-1 antibody;CIS1 antibody;Cish antibody;CISH_HUMAN antibody;Cytokine inducible inhibitor of signaling type 1B antibody;Cytokine inducible SH2 containing protein antibody;Cytokine-inducible SH2-containing protein antibody;G18 antibody;Protein G18 antibody;SOCS antibody;Suppressor of cytokine signaling antibody

SUBCELLULAR LOCATION

Cytosol, plasma membrane, phosphatidylinositol 3-kinase complex.

FUNCTION

The protein encoded by this gene contains a SH2 domain and a SOCS box domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by IL2, IL3, GM-CSF and EPO in hematopoietic cells. Proteasome-mediated degradation of this protein has been shown to be involved in the inactivation of the erythropoietin receptor. Multiple transcript variants encoding different isoforms have been found for this gene.

CITATIONS

  • Therapeutic potential of icariin in rats with letrozole and high-fat diet-induced polycystic ovary syndrome.

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