Paxillin Recombinant Rabbit Monoclonal Antibody [SY23-02] (ET1607-22)

UNIPROT #

P49023

PROTEIN NAME

Paxillin

SYNONYMS

FLJ16691 antibody;FLJ23042 antibody;Paired box protein Pax 1 antibody;PAX 1 antibody;PAX1 antibody;PAXI_HUMAN antibody;Paxillin alpha antibody;Paxillin antibody;PXN antibody;PXN protein antibody

SEQUENCE SIMILARITIES

Belongs to the paxillin family.

POST-TRANSLATIONAL MODIFICATION

Phosphorylated by MAPK1/ERK2 (By similarity). Phosphorylated on tyrosine residues during integrin-mediated cell adhesion, embryonic development, fibroblast transformation and following stimulation of cells by mitogens. Phosphorylation at Ser-244 by CDK5 reduces its interaction with PTK2/FAK1 in matrix-cell focal adhesions (MCFA) during oligodendrocytes (OLs) differentiation. Phosphorylation at Tyr-31 and Tyr-118 by PTK6 promote the activation of RAC1 via CRK/CrKII, thereby promoting migration and invasion. Phosphorylation at Ser-250 by SLK is required for PXN redistribution and cell motility.

SUBCELLULAR LOCATION

Cytoplasm, Cell junction.

FUNCTION

Paxillin is a focal adhesion phosphoprotein that is localized to the cytoskeleton. Phosphorylation of paxillin has been shown to occur in response to PDGF treatment, v-Src transformation or cross-linking of integrins. FAK (focal adhesion kinase) and PYK2 have been shown to phosphorylate paxillin. FAK phosphorylates paxillin specifically on Tyr 118 in vitro. However, FAK phosphorylation does not seem to be required for the recruitment of paxillin to cell adhesion sites. Paxillin may play a role in signal transduction, regulation of cell morphology and the recruitment of structural and signaling molecules to focal adhesions. It has been shown that the amount of paxillin is reduced in mitotic cells by proteolytic downregulation and that paxillin is alternatively phosphorylated on serine rather than on tyrosine and serine during mitosis.