IL-3RA Rabbit Polyclonal Antibody (HA500291)

UNIPROT #

P26951

PROTEIN NAME

IL-3RA

SYNONYMS

CD123 antibody;CD123 antigen antibody;hIL 3Ra antibody;hIL-3Ra antibody;hIL3Ra antibody;IL 3 receptor alpha SP2 isoform antibody;IL 3R alpha antibody;IL-3 receptor subunit alpha antibody;IL-3R subunit alpha antibody;IL-3R-alpha antibody;IL-3RA antibody;IL3 Receptor alpha antibody;IL3R antibody;Il3ra antibody;IL3RA_HUMAN antibody;IL3RAX antibody;IL3RAY antibody;IL3RX antibody;IL3RY antibody;Interleukin 3 receptor alpha chain antibody;Interleukin 3 receptor, alpha (low affinity) antibody;Interleukin 3 receptor, alpha antibody;Interleukin-3 Receptor alpha antibody;Interleukin-3 receptor subunit alpha antibody;Interleukin3 receptor antibody;Interleukin3 receptor, Y-chromosomal antibody

SUBCELLULAR LOCATION

Membrane.

FUNCTION

The protein encoded by this gene is an interleukin 3 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL3 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL3. This gene and the gene encoding the colony stimulating factor 2 receptor alpha chain (CSF2RA) form a cytokine receptor gene cluster in a X-Y pseudoautosomal region on chromosomes X or Y. Alternatively spliced transcript variants encoding distinct isoforms have been found.