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LRP6 Mouse Monoclonal Antibody [A5E7] (HA600065)

Price: Regular price $350.00

Volume

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Catalog# HA600065

Mouse Monoclonal to LRP6

Tested for

  • WB

  • IHC-P

Reacts with

  • Human

This product has been cited in peer reviewed publications, see list HERE

Safety datasheet

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Specifications

Product Type

Mouse monoclonal primary

Product Name

LRP6 Mouse Monoclonal Antibody [A5E7] (HA600065)

Immunogen

Recombinant protein within human lrp6 aa 100-300 / 1613.

Host

Mouse

Positive Control

Hela cell lysates, human colon tissue.

Conjugation

Unconjugated

Clonality

Monoclonal

Clone Number

A5E7

RRID

AB_3071682

APPLICATION DILUTION

  • WB

  • 1:500-1:2,000

  • IHC-P

  • 1:50-1:200

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

2ug/ul

Purification

Protein G affinity purified.

Molecular Weight

180 kDa

Isotype

IgG2b

TARGET

UNIPROT #

O75581

PROTEIN NAME

LRP6

SYNONYMS

ADCAD2 antibody;C030016K15Rik antibody;Cd antibody;FLJ90062 antibody;FLJ90421 antibody;LDL receptor related protein 6 antibody;Low density lipoprotein receptor related protein 6 antibody;Low-density lipoprotein receptor-related protein 6 antibody;LRP-6 antibody;LRP6 antibody;LRP6_HUMAN antibody;OTTHUMP00000238979 antibody;OTTHUMP00000238980 antibody;OTTHUMP00000238982 antibody;STHAG7 antibody

SUBCELLULAR LOCATION

Endoplasmic reticulum, Cell membrane, Membrane raft.

FUNCTION

Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Required for posterior patterning of the epiblast during gastrulation.

CITATIONS

  • Circulating neutrophils activated by cancer cells and M2 macrophages promote gastric cancer progression during PD-1 antibody-based immunotherapy

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