Versican Recombinant Rabbit Monoclonal Antibody [JB42-32] (ET7107-09)

UNIPROT #

P13611

PROTEIN NAME

Versican

SYNONYMS

Chondroitin sulfate proteoglycan 2 antibody;Chondroitin sulfate proteoglycan core protein 2 antibody;Chondroitin sulfate proteoglycan core protein, cartilage antibody;CSPG2 antibody;CSPG2_HUMAN antibody;ERVR antibody;GHAP antibody;Glial hyaluronate binding protein antibody;Glial hyaluronate-binding protein antibody;Large fibroblast proteoglycan antibody;PG-M antibody;PGM antibody;VCAN antibody;Versican antibody;Versican core protein antibody;Versican proteoglycan antibody;WGN 1 antibody;WGN antibody;WGN1 antibody

SEQUENCE SIMILARITIES

Belongs to the aggrecan/versican proteoglycan family.

TISSUE SPECIFICITY

Expressed in the retina (at protein level). Cerebral white matter and plasma. Isoform V0: Expressed in normal brain, gliomas, medulloblastomas, schwannomas, neurofibromas, and meningiomas. Isoform V1: Expressed in normal brain, gliomas, medulloblastomas, schwannomas, neurofibromas, and meningiomas. Isoform V2: Restricted to normal brain and gliomas. Isoform V3: Found in all these tissues except medulloblastomas.

DEVELOPMENTAL STAGE

Expressed in developing photoreceptors and the interphotoreceptor matrix between 12 and 17 weeks post conception (at protein level). Disappears in aorta after the cartilage development.

POST-TRANSLATIONAL MODIFICATION

Phosphorylated by FAM20C in the extracellular medium.

SUBCELLULAR LOCATION

Extracellular matrix. Secreted.

FUNCTION

Versican (chondroitin sulfate proteoglycan 2) is a large extracellular matrix proteoglycan involved in cell growth and differentiation. Important as a structural molecule, versican creates loose and hydrated matrices during key events in development and disease. The protein contains hyaluronic acid and glycosminoglycan-binding domains, epidermal growth factor-like repeats, a lectin-like sequence and a complement regulatory protein-like domain. Splice variants differ greatly in length and degree of modification by glycosaminoglycan chains. Accumulation around smooth muscle cells in lesions of atherosclerosis, suggests a role for versican in atherogenesis. Versican, differentially expressed in human melanoma, plays a role in tumor development and may be a reliable marker for clinical diagnosis. The organization of HA- and versican-rich pericellular matrices may faciliatate migration and mitosis by diminishing cell surface adhesivity and affecting cell shape through steric exclusion and the viscous properties of HA proteoglycan gels. The human verisican gene maps to chromosome 5q14.3.