WDR68 Recombinant Rabbit Monoclonal Antibody [JE61-64] (HA720062)

UNIPROT #

P61962

PROTEIN NAME

WDR68

SYNONYMS

AN11 antibody;Dcaf7 antibody;DCAF7_HUMAN antibody;DDB1- and CUL4-associated factor 7 antibody;HAN11 antibody;Human anthocyanin antibody;Petunia antibody;Seven WD repeat protein of the AN11 family 1 antibody;SWAN 1 antibody;WD repeat domain 68 antibody;WD repeat protein An11 homolog antibody;WD repeat-containing protein 68 antibody;WD repeat-containing protein An11 homolog antibody;WDR68 antibody

SUBCELLULAR LOCATION

Nucleus, Cytoplasm.

FUNCTION

This gene encodes a protein with multiple WD40 repeats which facilitate protein-protein interactions and thereby enable the assembly of multiprotein complexes. This protein has been shown to function as a scaffold protein for protein complexes involved in kinase signaling. This highly conserved gene is present in eukaryotic plants, fungi, and animals. Alternative splicing results in multiple transcript variants. Involved in craniofacial development. Acts upstream of the EDN1 pathway and is required for formation of the upper jaw equivalent, the palatoquadrate. The activity required for EDN1 pathway function differs between the first and second arches (By similarity). Associates with DIAPH1 and controls GLI1 transcriptional activity. Could be involved in normal and disease skin development. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. This protein is involved in the pathway protein ubiquitination, which is part of Protein modification. View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.