PD-L1 Recombinant Rabbit Monoclonal Antibody [JJ08-95] (ET1701-41)

UNIPROT #

Q9NZQ7

PROTEIN NAME

PD-L1

SYNONYMS

B7 H antibody;B7 H1 antibody;B7 homolog 1 antibody;B7-H1 antibody;B7H antibody;B7H1 antibody;CD 274 antibody;CD274 antibody;CD274 antigen antibody;CD274 molecule antibody;MGC142294 antibody;MGC142296 antibody;OTTHUMP00000021029 antibody;PD L1 antibody;PD-L1 antibody;PD1L1_HUMAN antibody;PDCD1 ligand 1 antibody;PDCD1L1 antibody;PDCD1LG1 antibody;PDL 1 antibody;PDL1 antibody;Programmed cell death 1 ligand 1 antibody;Programmed death ligand 1 antibody;RGD1566211 antibody

SEQUENCE SIMILARITIES

Belongs to the immunoglobulin superfamily. BTN/MOG family.

TISSUE SPECIFICITY

Highly expressed in the heart, skeletal muscle, placenta and lung. Weakly expressed in the thymus, spleen, kidney and liver. Expressed on activated T- and B-cells, dendritic cells, keratinocytes and monocytes.

POST-TRANSLATIONAL MODIFICATION

Ubiquitinated; STUB1 likely mediates polyubiquitination of PD-L1/CD274 triggering its degradation.

SUBCELLULAR LOCATION

Cell membrane, Endomembrane system.

FUNCTION

Engagement of CD28 by B7-1 (CD80) or B7-2 (CD86) in the presence of antigen promotes T cell proliferation, cytokine production, differentiation of effector T cells, and the induction of Bcl-x, a promoter of T cell survival. Conversely, engagement of CTLA4 by B7-1 or B7-2 may inhibit proliferation and IL-2 production. Pdcd-1L1 (programmed cell death ligand-1), also known as B7-H1 or PD-L1, is 290 amino acid type I transmembrane protein which is 20% and 15% identical to B7-1 and B7-2, respectively. Pdcd-1L2 has immunoglobulin V-like and C-like domains and a 30 amino acid cytoplasmic tail. It does not bind CD28, cytotoxic T-lymphocyte A4 or ICOS (inducible co-stimulator). IL-2, although produced in small amounts, is required for the effect of Pdcd-1L1 co-stimulation. The gene which encodes Pdcd-1L1 maps to human chromosome 9p24. Pdcd-1L2 (programmed cell death ligand-2) is a 73 amino acid protein which contains a signal sequence, IgV- and IgC-like domains, a transmembrane region and a cytoplasmic region. The gene which encodes Pdcd-1L2 maps to human chromosome 9p24.2. The constitutive expression of Pdcd-1L1 and Pdcd-1L2 on paren-chymal cells of heart, lung and kidney suggests that the Pdcd-1-Pdcd-L system could provide unique negative signaling to help prevent autoimmune disease.