67kDa Laminin Receptor Recombinant Rabbit Monoclonal Antibody [JF0955] (ET1702-05)

UNIPROT #

P08865

PROTEIN NAME

67kDa Laminin Receptor

SYNONYMS

34/67 kDa laminin receptor antibody;37 kDa laminin receptor precursor antibody;37/67 kDa laminin receptor antibody;37LRP antibody;40S ribosomal protein SA antibody;67 kDa laminin receptor antibody;67LR antibody;Colon carcinoma laminin binding protein antibody;Colon carcinoma laminin-binding protein antibody;LAMBR antibody;Laminin receptor 1 antibody;Laminin-binding protein precursor p40 antibody;LAMR 1 antibody;LamR antibody;LAMR1 antibody;LBP antibody;LBP/p40 antibody;LRP antibody;LRP/LR antibody;Multidrug resistance associated protein MGr1 Ag antibody;Multidrug resistance associated protein MGr1Ag antibody;Multidrug resistance-associated protein MGr1-Ag antibody;NEM/1CHD4 antibody;p40 antibody;Ribosomal Protein SA antibody;rpsA antibody;RSSA_HUMAN antibody;SA antibody

SEQUENCE SIMILARITIES

Belongs to the universal ribosomal protein uS2 family.

POST-TRANSLATIONAL MODIFICATION

Acylated. Acylation may be a prerequisite for conversion of the monomeric 37 kDa laminin receptor precursor (37LRP) to the mature dimeric 67 kDa laminin receptor (67LR), and may provide a mechanism for membrane association.; Cleaved by stromelysin-3 (ST3) at the cell surface. Cleavage by stromelysin-3 may be a mechanism to alter cell-extracellular matrix interactions.

SUBCELLULAR LOCATION

Cell membrane, Nucleus, Cytoplasm.

FUNCTION

Laminin receptor (Laminin-R) has a heterodimeric structure similar to that of receptors for other extracellular matrix proteins such as Fibronectin and Vitronectin. Incorporation of Laminin-R into lysosomal membranes makes it possible for lysosomes to attach to surfaces coated with Laminin. This and other properties identify Laminin-R as a member of the integrin family of cell adhesion receptors. The Laminin-R precursor is a polypeptide whose expression is consistently upregulated in aggressive carcinoma. The precursor, which is also identified as p40 ribosome-associated protein, appears to be a multifunctional protein involved in the translational machinery. Laminin-R (also known as colon carcinoma laminin-binding protein) and is found at nine-fold higher levels in colon carcinoma than in adjacent normal colonic epithelium. Additionally, the level of the Laminin-R is higher in the lung cancer cell line than in the lung cell line.