Laminin 2 alpha Recombinant Rabbit Monoclonal Antibody [PSH0-94] (HA721532)

UNIPROT #

P24043

PROTEIN NAME

Laminin 2 alpha

SYNONYMS

LAMA 2 antibody;LAMA2 antibody;LAMA2_HUMAN antibody;Laminin alpha 2 (merosin congenital muscular dystrophy) antibody;Laminin alpha 2 antibody;Laminin alpha 2 chain antibody;Laminin alpha 2 subunit antibody;Laminin M antibody;Laminin M chain antibody;Laminin subunit alpha-2 antibody;Laminin-12 subunit alpha antibody;Laminin-2 subunit alpha antibody;Laminin-4 subunit alpha antibody;LAMM antibody;Merosin heavy chain antibody

SUBCELLULAR LOCATION

Secreted, extracellular space, extracellular matrix, basement membrane.

FUNCTION

Laminin subunit alpha-2 is a protein that in humans is encoded by the LAMA2 gene. Laminin, an extracellular matrix protein, is a major component of the basement membrane. It is thought to mediate the attachment, migration, and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. It is composed of three subunits, alpha, beta, and gamma, which are bound to each other by disulfide bonds into a cross-shaped molecule. This gene encodes the alpha 2 chain, which constitutes one of the subunits of laminin 2 (merosin) and laminin 4 (s-merosin). Mutations in this gene have been identified as the cause of congenital merosin-deficient muscular dystrophy. Two transcript variants encoding different proteins have been found for this gene.