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CTHRC1 Mouse Monoclonal Antibody [5H1] (EM1701-36)

Price: Regular price $350.00

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Catalog# EM1701-36

Mouse Monoclonal to CTHRC1

Tested for

  • WB

  • IHC-P

Reacts with

  • Human

  • Rat

  • Mouse

This product has been cited in peer reviewed publications, see list HERE

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Specifications

Product Type

Mouse monoclonal primary

Product Name

CTHRC1 Mouse Monoclonal Antibody [5H1] (EM1701-36)

Immunogen

Recombinant protein within human cthrc1 aa 1-243 / 243.

Host

Mouse

Positive Control

CTHRC1 recombinant protein, rat large intestine tissue, human kidney tissue, human placenta tissue.

Conjugation

Unconjugated

Clonality

Monoclonal

Clone Number

5H1

RRID

AB_3068761

APPLICATION DILUTION

  • WB

  • 1:500-1:1,000

  • IHC-P

  • 1:50-1:200

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

2ug/ul

Purification

Protein A affinity purified.

Molecular Weight

Predicted band size: 26 kDa

Isotype

IgG1

TARGET

UNIPROT #

Q96CG8

PROTEIN NAME

CTHRC1

SYNONYMS

Collagen triple helix repeat containing 1 antibody;Collagen triple helix repeat containing protein 1 antibody;Collagen triple helix repeat-containing protein 1 antibody;CTHR1_HUMAN antibody;Cthrc1 antibody;NMTC1 protein antibody;Protein NMTC1 antibody

TISSUE SPECIFICITY

Isoform 1 is expressed in calcified atherosclerotic plaque and chondrocyte-like cells.

POST-TRANSLATIONAL MODIFICATION

N-glycosylated.

SUBCELLULAR LOCATION

Extracellular matrix. Secreted.

FUNCTION

CTHRC1 (collagen triple helix repeat containing 1) is a 243 amino acid secreted protein that localizes to the extracellular matrix and contains one collagen-like domain. Expressed as two alternatively spliced isoforms, the first of which is expressed in calcified atherosclerotic plaque and chondrocyte-like cells, CTHRC1 is thought to function as a negative regulator of collagen matrix deposition and may also play a role in the stabilization of ligand-receptor interactions in the Wnt pathway. CTHRC1 is widely present in a variety of cancers, including melanoma and breast carcinoma, and may participate in cancer cell migration and cancer tissue invasion and metastasis. The gene encoding CTHRC1 maps to human chromosome 8, which consists of nearly 146 million base pairs, houses more than 800 genes and is associated with a variety of diseases and malignancies.

CITATIONS

  • Zhang ZG

    CTHRC1 acts as a prognostic factor and promotes invasiveness of gastrointestinal stromal tumors by activating Wnt/PCP-Rho signaling.

  • Xiao-Mei Yang

    CTHRC1 promotes human colorectal cancer cell proliferation and invasiveness by activating Wnt/PCP signaling

  • Qing Xu,Zhigang Zhang

    Autocrine CTHRC1 activates hepatic stellate cells and promotes liver fibrosis by activating TGF-β signaling

  • Lv Xinyi,et al

    Analysis of subsets and localization of macrophages in skin lesions and peripheral blood of patients with keloids

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