LOXL2 Recombinant Rabbit Monoclonal Antibody [JU32-53] (ET1706-11)

UNIPROT #

Q9Y4K0

PROTEIN NAME

LOXL2

SYNONYMS

LOR 2 antibody;LOR2 antibody;LOX L2 antibody;LOXL 2 antibody;LOXL2 antibody;LOXL2_HUMAN antibody;Lysyl oxidase homolog 2 antibody;Lysyl oxidase like 2 antibody;Lysyl oxidase like protein 2 antibody;Lysyl oxidase related 2 antibody;Lysyl oxidase related protein 2 antibody;Lysyl oxidase related protein WS9 14 antibody;Lysyl oxidase-like protein 2 antibody;Lysyl oxidase-related protein 2 antibody;Lysyl oxidase-related protein WS9-14 antibody;WS9 14 antibody

SEQUENCE SIMILARITIES

Belongs to the lysyl oxidase family.

TISSUE SPECIFICITY

Expressed in many tissues. Highest expression in reproductive tissues, placenta, uterus and prostate. In esophageal epithelium, expressed in the basal, prickle and granular cell layers. Up-regulated in a number of cancers cells and tissues.

POST-TRANSLATIONAL MODIFICATION

The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.; N-glycosylated. N-glycosylation on Asn-455 and Asn-644 may be essential for proper folding and secretion; may be composed of a fucosylated carbohydrates attached to a trimannose N-linked glycan core.

SUBCELLULAR LOCATION

Secreted, Nucleus.

FUNCTION

Lysyl oxidase homolog 2 is an enzyme that in humans is encoded by the LOXL2 gene.This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family.LOXL2 can also crosslink collagen type IV and hence influence the sprouting of new blood vessels. LOXL2 is an enzyme that is up-regulated in several types of cancer and is associated with a poorer prognosis.LOXL2 changes the structure of histones (proteins that are attached to DNA) and thus changes the shape of the cells, making it easier for the cancer cells to metastasize.