YKL-40 / CHI3L1 Mouse Monoclonal Antibody [10C1] (EM1902-14)

UNIPROT #

P36222

PROTEIN NAME

YKL-40 / CHI3L1

SYNONYMS

39 kDa synovial protein antibody;ASRT7 antibody;Cartilage glycoprotein 39 antibody;CGP-39 antibody;CGP39 antibody;CH3L1_HUMAN antibody;CHI3L1 antibody;chitinase 3 like 1 (cartilage glycoprotein 39) antibody;chitinase 3 like 1 antibody;Chitinase 3 like protein 1 precursor antibody;chitinase antibody;Chitinase-3-like protein 1 antibody;Chondrocyte protein YKL40 antibody;GP 39 antibody;GP-39 antibody;GP39 antibody;HC gp39 antibody;HCGP 3P antibody;hCGP-39 antibody;HCgp39 antibody;YKL 40 antibody;YKL-40 antibody;YKL40 antibody;YYL 40 antibody

SEQUENCE SIMILARITIES

Belongs to the glycosyl hydrolase 18 family.

TISSUE SPECIFICITY

Present in activated macrophages, articular chondrocytes, synovial cells as well as in liver. Very low or undetectable expression in non-inflammatory colon. Undetectable in muscle tissues, lung, pancreas, mononuclear cells, or fibroblasts.

POST-TRANSLATIONAL MODIFICATION

Glycosylated.

SUBCELLULAR LOCATION

Cytoplasm, Endoplasmic reticulum, Secreted.

FUNCTION

Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a role in T-helper cell type 2 (Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation. Facilitates invasion of pathogenic enteric bacteria into colonic mucosa and lymphoid organs. Mediates activation of AKT1 signaling pathway and subsequent IL8 production in colonic epithelial cells. Regulates antibacterial responses in lung by contributing to macrophage bacterial killing, controlling bacterial dissemination and augmenting host tolerance. Also regulates hyperoxia-induced injury, inflammation and epithelial apoptosis in lung.