Growth hormone receptor Recombinant Rabbit Monoclonal Antibody [JU01-34] (ET1706-49)

UNIPROT #

P10912

PROTEIN NAME

Growth hormone receptor

SYNONYMS

GH receptor antibody;GH-binding protein antibody;GHBP antibody;GHBP, included antibody;GHR antibody;GHR_HUMAN antibody;Growth hormone binding protein antibody;Growth hormone receptor antibody;Growth hormone receptor precursor antibody;Growth hormone-binding protein antibody;Growth hormone-binding protein, included antibody;Increased responsiveness to growth hormone, included antibody;Serum binding protein antibody;Serum-binding protein antibody;Somatotropin receptor antibody

SEQUENCE SIMILARITIES

Belongs to the type I cytokine receptor family. Type 1 subfamily.

TISSUE SPECIFICITY

Expressed in various tissues with high expression in liver and skeletal muscle. Isoform 4 is predominantly expressed in kidney, bladder, adrenal gland and brain stem. Isoform 1 expression in placenta is predominant in chorion and decidua. Isoform 4 is highly expressed in placental villi. Isoform 2 is expressed in lung, stomach and muscle. Low levels in liver.

POST-TRANSLATIONAL MODIFICATION

The soluble form (GHBP) is produced by phorbol ester-promoted proteolytic cleavage at the cell surface (shedding) by ADAM17/TACE. Shedding is inhibited by growth hormone (GH) binding to the receptor probably due to a conformational change in GHR rendering the receptor inaccessible to ADAM17 (By similarity).; On GH binding, phosphorylated on tyrosine residues in the cytoplasmic domain by JAK2.; On ligand binding, ubiquitinated on lysine residues in the cytoplasmic domain. This ubiquitination is not sufficient for GHR internalization (By similarity).

SUBCELLULAR LOCATION

Secreted. Cell membrane.

FUNCTION

GHR (growth hormone receptor) binds growth hormone (GH), which is produced by the anterior pituitary and regulates body growth and other metabolic processes. GHR is an integral membrane protein and a member of the cytokine receptor family. A common characteristic of the cytokine receptor family is having soluble forms of the protein. The soluble form of GHR is GH-binding protein (GHBP), which is generated by the proteolytic cleavage of the extracellular domain of GHR (2-4). Reduced levels of GHBP are associated with GH insensitivity syndrome (GHIS) (2,4). GHR has been shown to be transcribed via at least two different promoters, resulting in GHR 1A and GHR 1B. Both GHR 1A and 1B are expressed in liver, whereas GHR 1B is also expressed in muscle, uterus, and ovary tissues.