NR1D1 Recombinant Rabbit Monoclonal Antibody [JU34-31] (ET7106-92)

UNIPROT #

P20393

PROTEIN NAME

NR1D1

SYNONYMS

EAR-1 antibody;EAR1 antibody;ERBA-related 1 antibody;hRev antibody;Nr1d1 antibody;NR1D1_HUMAN antibody;Nuclear receptor Rev ErbA alpha antibody;Nuclear receptor subfamily 1 group D member 1 antibody;Rev erbAalpha antibody;Rev erbalpha antibody;Rev-erbA-alpha antibody;Rev-ErbAalpha antibody;Reverba antibody;THRA1 antibody;THRAL antibody;Thyroid hormone receptor, alpha like antibody;Thyroid hormone receptor, alpha-1- like antibody;V-erbA-related protein 1 antibody

SEQUENCE SIMILARITIES

Belongs to the nuclear hormone receptor family. NR1 subfamily.

TISSUE SPECIFICITY

Widely expressed. Expressed at high levels in the liver, adipose tissue, skeletal muscle and brain. Also expressed in endothelial cells (ECs), vascular smooth muscle cells (VSMCs) and macrophages. Expression oscillates diurnally in the suprachiasmatic nucleus (SCN) of the hypothalamus as well as in peripheral tissues. Expression increases during the differentiation of pre-adipocytes into mature adipocytes. Expressed at high levels in some squamous carcinoma cell lines.

POST-TRANSLATIONAL MODIFICATION

Ubiquitinated, leading to its proteasomal degradation. Ubiquitinated by SIAH2; leading to its proteasomal degradation. Ubiquitinated by the SCF(FBXW7) complex when phosphorylated by CDK1 leading to its proteasomal degradation (By similarity). Rapidly ubiquitinated in response to inflammatory triggers and sumoylation is a prerequisite to its ubiquitination (By similarity).; Sumoylated by UBE2I, desumoylated by SENP1, and sumoylation is a prerequisite to its ubiquitination.; Phosphorylated by CSNK1E; phosphorylation enhances its cytoplasmic localization.; Undergoes lysosome-mediated degradation in a time-dependent manner in the liver.

SUBCELLULAR LOCATION

Nucleus, Cytoplasm, Cell projection, dendrite, dendritic spine.

FUNCTION

Transcriptional repressor which coordinates circadian rhythm and metabolic pathways in a heme-dependent manner. Integral component of the complex transcription machinery that governs circadian rhythmicity and forms a critical negative limb of the circadian clock by directly repressing the expression of core clock components ARTNL/BMAL1, CLOCK and CRY1. Also regulates genes involved in metabolic functions, including lipid and bile acid metabolism, adipogenesis, gluconeogenesis and the macrophage inflammatory response. Acts as a receptor for heme which stimulates its interaction with the NCOR1/HDAC3 corepressor complex, enhancing transcriptional repression. Recognizes two classes of DNA response elements within the promoter of its target genes and can bind to DNA as either monomers or homodimers, depending on the nature of the response element. Binds as a monomer to a response element composed of the consensus half-site motif 5'-[A/G]GGTCA-3' preceded by an A/T-rich 5' sequence (RevRE), or as a homodimer to a direct repeat of the core motif spaced by two nucleotides (RevDR-2).