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BMP11 Rabbit Polyclonal Antibody (R1510-15)

Price: Regular price $315.00

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Catalog# R1510-15

Rabbit Polyclonal to BMP11

Tested for

  • WB

  • IF-Cell

  • IHC-P

  • FC

Reacts with

  • Human

  • Mouse

  • Rat

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Specifications

Product Type

Rabbit polyclonal primary

Product Name

BMP11 Rabbit Polyclonal Antibody (R1510-15)

Immunogen

Recombinant protein within human bmp11 aa 200-407.

Host

Rabbit

Positive Control

Hela, SW480, HepG2, human colon cancer tissue, mouse brain tissue.

Conjugation

Unconjugated

Clonality

Polyclonal

RRID

AB_3073323

APPLICATION DILUTION

  • IF-Cell

  • 1:50-1:200

  • IHC-P

  • 1:50-1:200

  • FC

  • 1:50-1:100

  • WB

  • 1:500

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1ug/ul

Purification

Protein A affinity purified.

Molecular Weight

Predicted band size: 45 kDa

Isotype

IgG

TARGET

UNIPROT #

O95390

PROTEIN NAME

BMP11

SYNONYMS

BMP 11 antibody;BMP-11 antibody;BMP11 antibody;Bone morphogenetic protein 11 antibody;GDF 11 antibody;GDF-11 antibody;Gdf11 antibody;GDF11_HUMAN antibody;Growth differentiation factor 11 antibody;Growth/differentiation factor 11 antibody

SEQUENCE SIMILARITIES

Belongs to the TGF-beta family.

POST-TRANSLATIONAL MODIFICATION

Synthesized as large precursor molecule that undergoes proteolytic cleavage. The mature C-terminal portion of the molecule is bound non-covalently to its N-terminal propeptide rendering it inactive. Ligand activation requires additional cleavage of the prodomain by a tolloid-like metalloproteinase.

SUBCELLULAR LOCATION

Secreted.

FUNCTION

GDF-11, a member of the Transforming Growth Factor (TGF) Beta superfamily, controls anterior/posterior patterning of the axial skeleton, regulates organogenesis by controlling expression of Gdnf, contributes to the control of Hox gene expression, and induces phosphorylation of Smad2. In addition, GDF-11 mediates signaling of Nodal during left-right patterning and development of head structures and inhibits generation of new neurons by neuronal progenitors in the olfactory epithelium.

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