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ALDH2 Mouse Monoclonal Antibody [7-D8] (M1501-7)

Price: Regular price $350.00

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Catalog# M1501-7

Mouse Monoclonal to ALDH2

Tested for

  • WB

  • IF-Cell

  • IHC-P

Reacts with

  • Human

  • Mouse

  • Rat

This product has been cited in peer reviewed publications, see list HERE

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Specifications

Product Type

Mouse monoclonal primary

Product Name

ALDH2 Mouse Monoclonal Antibody [7-D8] (M1501-7)

Immunogen

Synthetic peptide within human aldh2 aa 1-50 / 517.

Host

Mouse

Positive Control

293T cell lysate, HepG2 cell lysate, K-562 cell lysate, A549 cell lysate, THP-1 cell lysate, human liver tissue lysate, mouse liver tissue lysate, rat liver tissue lysate, rat testis tissue lysate, HepG2, human gastric carcinoma tissue, human colon carcinoma tissue, human liver tissue, mouse liver tissue, rat liver tissue.

Conjugation

Unconjugated

Clonality

Monoclonal

Clone Number

7-D8

RRID

AB_3073097

APPLICATION DILUTION

  • WB

  • 1:1,000

  • IF-Cell

  • 1:100-1:200

  • IHC-P

  • 1:200-1:500

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

2ug/ul

Purification

Protein A affinity purified.

Molecular Weight

Predicted band size: 56 kDa

Isotype

IgG1

TARGET

UNIPROT #

P05091

PROTEIN NAME

ALDH2

SYNONYMS

Acetaldehyde dehydrogenase 2 antibody;Aldehyde dehydrogenase 2 family (mitochondrial) antibody;Aldehyde dehydrogenase 2 family antibody;Aldehyde dehydrogenase mitochondrial antibody;Aldehyde dehydrogenase, mitochondrial antibody;ALDH 2 antibody;ALDH class 2 antibody;ALDH E2 antibody;ALDH-E2 antibody;Aldh2 antibody;ALDH2_HUMAN antibody;ALDHI antibody;ALDM antibody;Liver mitochondrial ALDH antibody;MGC1806 antibody;Mitochondrial aldehyde dehydrogenase 2 antibody;MS767 antibody;Nucleus encoded mitochondrial aldehyde dehydrogenase 2 antibody

SEQUENCE SIMILARITIES

Belongs to the aldehyde dehydrogenase family.

SUBCELLULAR LOCATION

Mitochondrion matrix.

FUNCTION

Aldehyde dehydrogenase 2 family (mitochondrial), also known as ALDH2, is a human gene found on chromosome 12. Two major liver isoforms of this enzyme, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. The ALDH2 gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix. Most Europeans have two major isozymes, while approximately 50% of Northeast Asians have one normal copy of the ALDH2 gene and one mutant copy that encodes an inactive mitochondrial isoenzyme. A remarkably higher frequency of acute alcohol intoxication among Northeast Asians than among Europeans has been repeatedly shown to be related to the very much reduced activity of the mutant ALDH2-2 isoenzyme.

CITATIONS

  • Liu, X., Xiao, W., Zhang, Y., Wiley, S. E., Zuo, T., Zheng, Y., Chen, N., Chen, L., Wang, X., Zheng, Y., Huang, L., Lin, S., Murphy, A. N., Dixon, J. E., Xu, P., & Guo, X.

    Reversible phosphorylation of Rpn1 regulates 26S proteasome assembly and function

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