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CYP1B1 Rabbit Polyclonal Antibody (HA500494)

Price: Regular price $315.00

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Catalog# HA500494

Rabbit Polyclonal to CYP1B1

Tested for

  • WB

  • IHC-P

Reacts with

  • Human

  • Rat

This product has been cited in peer reviewed publications, see list HERE

Safety datasheet

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Specifications

Product Type

Rabbit polyclonal primary

Product Name

CYP1B1 Rabbit Polyclonal Antibody (HA500494)

Immunogen

Recombinant protein within human cyp1b1 aa 231-400.

Host

Rabbit

Positive Control

A549 cell lysate, Hela cell lysate, rat skeletal muscle tissue.

Conjugation

Unconjugated

Clonality

Polyclonal

RRID

AB_3071579

APPLICATION DILUTION

  • WB

  • 1:500-1:1,000

  • IHC-P

  • 1:50-1:200

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1ug/ul

Purification

Immunogen affinity purified.

Molecular Weight

Predicted band size: 61 kDa.

Isotype

IgG

TARGET

UNIPROT #

Q16678

PROTEIN NAME

CYP1B1

SYNONYMS

Aryl hydrocarbon hydroxylase antibody;CP1B antibody;CP1B1_HUMAN antibody;Cyp1b1 antibody;CYPIB1 antibody;Cytochrome P450 1B1 antibody;Cytochrome P450 family 1 subfamily B polypeptide 1 antibody;Cytochrome P450 subfamily I (dioxin inducible) polypeptide 1 (glaucoma 3 primary infantile) antibody;Flavoprotein linked monooxygenase antibody;GLC3A antibody;Microsomal monooxygenase antibody;P4501B1 antibody;Xenobiotic monooxygenase antibody

SUBCELLULAR LOCATION

Mitochondrion, Endoplasmic reticulum membrane, Microsome membrane.

FUNCTION

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The enzyme encoded by this gene localizes to the endoplasmic reticulum and metabolizes procarcinogens such as polycyclic aromatic hydrocarbons and 17beta-estradiol. Mutations in this gene have been associated with primary congenital glaucoma; therefore it is thought that the enzyme also metabolizes a signaling molecule involved in eye development, possibly a steroid.

CITATIONS

  • Hao Lin,et al

    The crucial involvement of gamma-Mangostin and CYP1B1 in the mechanism underlying the toxicity caused by cigarette smoke extract: In silico and in vitro insights

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