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CYP2E1 Recombinant Rabbit Monoclonal Antibody [JM10-85] (ET1703-48)

Price: Regular price $385.00

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Catalog# ET1703-48

Rabbit Monoclonal to CYP2E1

Tested for

  • WB

  • IF-Tissue

  • IHC-P

Reacts with

  • Human

  • Mouse

  • Rat

Recombinant production enables lot-to-lot consistency and is animal-cruelty-free
This product has been cited in peer reviewed publications, see list HERE

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Specifications

Product Type

Recombinant Rabbit monoclonal primary

Product Name

CYP2E1 Recombinant Rabbit Monoclonal Antibody [JM10-85] (ET1703-48)

Immunogen

Synthetic peptide within human cyp2e1 aa 71-114 / 439.

Host

Rabbit

Positive Control

Human liver tissue lysates, Mouse liver tissue lysate, Rat liver tissue lysate, human liver tissue, mouse liver tissue, rat liver tissue.

Conjugation

Unconjugated

Clonality

Monoclonal

Clone Number

JM10-85

RRID

AB_3070404

APPLICATION DILUTION

  • WB

  • 1:1,000-1:5,000

  • IF-Tissue

  • 1:50-1:200

  • IHC-P

  • 1:50-1:200

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1ug/ul

Purification

Protein A affinity purified.

Molecular Weight

Predicted band size: 57 kDa

Isotype

IgG

TARGET

UNIPROT #

P05181

PROTEIN NAME

CYP2E1

SYNONYMS

4-nitrophenol 2-hydroxylase antibody;CP2E1_HUMAN antibody;CPE1 antibody;CYP2E antibody;Cyp2e1 antibody;CYPIIE1 antibody;Cytochrome P450 2E1 antibody;Cytochrome P450 isozyme 3A antibody;Cytochrome P450 LM3A antibody;Cytochrome P450, family 2, subfamily e, polypeptide 1 antibody;cytochrome P450, subfamily IIE (ethanol-inducible), polypeptide 1 antibody;Cytochrome P450, subfamily IIE antibody;Cytochrome P450-ALC antibody;Cytochrome P450-J antibody;Cytochrome P450RLM6 antibody;EC 1.14.13.- antibody;EC 1.14.13.n7 antibody;Ethanol-inducible P450 antibody;Flavoprotein-linked monooxygenase antibody;MGC133529 antibody;Microsomal monooxygenase antibody;OTTHUMP00000020813 antibody;OTTHUMP00000046571 antibody;P450 ALC antibody;P450-J antibody;P450C2E antibody;P450J antibody;P450RLM6 antibody;Xenobiotic monooxygenase antibody

SEQUENCE SIMILARITIES

Belongs to the cytochrome P450 family.

SUBCELLULAR LOCATION

Endoplasmic reticulum, Membrane, Microsome, Mitochondrion, Mitochondrion inner membrane.

FUNCTION

A cytochrome P450 monooxygenase involved in the metabolism of fatty acids . Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) .Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics (Probable).

CITATIONS

  • Lu, S., Zhao, J., Chen, X., Xu, S., Yang, X., Zhang, Y., Ma, Z., Jiang, H., & Zhou, H.

    Proton pump inhibitor-induced risk of chronic kidney disease is associated with increase of indoxyl sulfate synthesis via inhibition of CYP2E1 protein degradation

  • Jiang Lu,et al

    Spatial transcriptomics reveals the transcriptomic signatures in a mouse model of pediatric metabolic dysfunction-associated steatohepatitis

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