ESD Rabbit Polyclonal Antibody (R1511-9)

UNIPROT #

P10768

PROTEIN NAME

ESD

SYNONYMS

EC 3.1.2.12 antibody;Es-10 antibody;Es10 antibody;ESD antibody;ESTD_HUMAN antibody;Esterase 10 antibody;Esterase D antibody;Esterase D formylglutathione hydrolase antibody;FGH antibody;FGH, included antibody;FLJ11763 antibody;Methylumbelliferyl acetate deacetylase antibody;MGC139609 antibody;OTTHUMP00000018374 antibody;OTTHUMP00000040929 antibody;S formylglutathione hydrolase antibody;S-formylglutathione hydrolase antibody;S-formylglutathione hydrolase, included antibody;Sid 478 antibody;sid478 antibody

SEQUENCE SIMILARITIES

Belongs to the esterase D family.

SUBCELLULAR LOCATION

Cytoplasm, Cytoplasmic vesicle.

FUNCTION

ESD (esterase D) is also known as S-formylglutathione hydrolase and is a 282 amino acid protein that is a member of the esterase D family. ESD is highly expressed in placenta, kidney, liver and erythrocytes, and is localized to the cytoplasm, as well as to cytoplasmic vesicles. The main function of ESD is to detoxify formaldehyde while providing energy. Formaldehyde is oxidized by ADH5 which yields S-formylglutathione. ESD then catalyzes the hydrolysis of S-formylglutathione to the reduced forms of formic acid and glutathione. In addition, ESD hydrolyzes a variety of different neutral ester substrates and can act as a carboxylesterase. ESD may also act as a cysteine hydrolase which is inactivated by thiol alkylating agents. ESD gene polymorphism can lead to reduced enzymatic activity which may cause susceptibility to many conditions, including toxic liver cirrhosis, retinoblastoma, obesity and autism.