Cytochrome P450 2D6 Recombinant Rabbit Monoclonal Antibody [JM44-23] (ET1705-28)

UNIPROT #

P10635

PROTEIN NAME

Cytochrome P450 2D6

SYNONYMS

CPD6 antibody;CYP2D antibody;CYP2D6 antibody;CYP2D7AP antibody;CYP2D7BP antibody;CYP2D7P2 antibody;CYP2D8P2 antibody;CYP2DL1 antibody;CYPIID6 antibody;Cytochrome P450 DB1 antibody;Cytochrome P450 family 2 subfamily D member 6 antibody;Cytochrome P450 family 2 subfamily D polypeptide 6 antibody;Debrisoquine 4 hydroxylase antibody;Flavoprotein linked monooxygenase antibody;Microsomal monooxygenase antibody;P450 DB1 antibody;P450C2D antibody;P450DB1 antibody;Xenobiotic monooxygenase antibody

SEQUENCE SIMILARITIES

Belongs to the cytochrome P450 family.

SUBCELLULAR LOCATION

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

FUNCTION

Cytochrome P450 2D6 (CYP2D6) is an enzyme that in humans is encoded by the CYP2D6 gene. CYP2D6 is primarily expressed in the liver. It is also highly expressed in areas of the central nervous system, including the substantia nigra. CYP2D6, a member of the cytochrome P450 mixed-function oxidase system, is one of the most important enzymes involved in the metabolism of xenobiotics in the body. In particular, CYP2D6 is responsible for the metabolism and elimination of approximately 25% of clinically used drugs, via the addition or removal of certain functional groups – specifically, hydroxylation, demethylation, and dealkylation. CYP2D6 also activates some prodrugs. This enzyme also metabolizes several endogenous substances, such as hydroxytryptamines, neurosteroids, and both m-tyramine and p-tyramine which CYP2D6 metabolizes into dopamine in the brain and liver.